Relationship between the classification of vascular invasion severity and the prognosis of uterine endometrial cancer

J. Kuroki, K. Hasegawa, R. Kato, J. Mizukawa, E. Nishio, Haruki Nishizawa, Yasuhiro Udagawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The objective of this research is whether the classification of vascular invasion severity can be used as a prognostic factor in cases of uterine endometrial cancer. Sixty-five patients with stage I to III uterine endometrial cancer were included in the study. All patients were seen between 1987 and 1997, and the types of their cancers were histologically confirmed. The degree of vascular invasion was classified according to three different systems: (1) positive or negative; (2) negative, mild, or severe; and (3) negative, mild, moderate, or severe. For each classification, the disease-free survival rate was calculated according to various pathologic factors using the Wilcoxon test; multivariate analyses were performed using the Cox proportional hazard model. Patients with severe vascular invasion showed a significantly lower disease-free survival rate than did patients with moderate or less severe invasion. In the multivariate analysis, severe vascular invasion was shown to be an independent prognostic factor indicating a high relative risk. We conclude that the severity of vascular invasion is an important histopathologic factor in determining the prognosis of uterine endometrial cancer. Vascular invasion classification systems employing three subjective or four objective categories may be more appropriate than a positive/negative classification system for judging the prognosis in cases of uterine endometrial cancer.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume13
Issue number1
DOIs
Publication statusPublished - 01-01-2003

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Uterine Neoplasms
Endometrial Neoplasms
Blood Vessels
Disease-Free Survival
Multivariate Analysis
Survival Rate
Proportional Hazards Models
Research
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Kuroki, J. ; Hasegawa, K. ; Kato, R. ; Mizukawa, J. ; Nishio, E. ; Nishizawa, Haruki ; Udagawa, Yasuhiro. / Relationship between the classification of vascular invasion severity and the prognosis of uterine endometrial cancer. In: International Journal of Gynecological Cancer. 2003 ; Vol. 13, No. 1. pp. 47-52.
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Relationship between the classification of vascular invasion severity and the prognosis of uterine endometrial cancer. / Kuroki, J.; Hasegawa, K.; Kato, R.; Mizukawa, J.; Nishio, E.; Nishizawa, Haruki; Udagawa, Yasuhiro.

In: International Journal of Gynecological Cancer, Vol. 13, No. 1, 01.01.2003, p. 47-52.

Research output: Contribution to journalArticle

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