TY - JOUR
T1 - Relationship between vegetable and carotene intake and risk of prostate cancer
T2 - The JACC study
AU - Umesawa, M.
AU - Iso, H.
AU - Mikami, K.
AU - Kubo, T.
AU - Suzuki, K.
AU - Watanabe, Y.
AU - Mori, M.
AU - Miki, T.
AU - Tamakoshi, A.
N1 - Funding Information:
The Japan Collaborative Cohort (JACC) Study for Evaluation of Cancer Risks, sponsored by the Ministry of Education, Sport, and Science, was conducted from 1988 to 1990. The sampling methods and protocols of the JACC Study have been described elsewhere (Tamakoshi et al, 2013). A total of 46 395 men, 40–79 years of age, completed self-administered questionnaires about their lifestyles and medical histories. Of them, we used the data of 26 429 men who lived in 24 communities that underwent follow-up research of cancer incidence. We additionally excluded 10 023 men owing to the lack of valid responses to dietary intake-related questions, and 935 men owing to the presence of past history of cancer and cardiovascular disease at baseline. Finally, we used the data of 15 471 men for analysis.
PY - 2014/2/4
Y1 - 2014/2/4
N2 - Background:We examined the associations of intakes of vegetables and carotenes with risk of prostate cancer in Japanese.Methods:A total of 15 471 Japanese men participating in the Japan Collaborative Cohort study completed a questionnaire including food intake. Of them, 143 incident prostate cancers were documented. We examined the associations stated above by using Cox proportional hazard model.Results:Vegetable intake was not associated with the risk of prostate cancer, but so was dietary alpha-carotene intake. The multivariable hazard ratio (95%CI) in the secondary highest and highest quintiles of alpha-carotene intake was 0.50 (0.26-0.98) (P=0.043) and 0.46 (0.22-0.97) (P=0.041) (P for trend=0.224), respectively. Beta-carotene intake was not associated with the risk of prostate cancer.Conclusion:Alpha-carotene intake was associated with lower risk of prostate cancer among Japanese.
AB - Background:We examined the associations of intakes of vegetables and carotenes with risk of prostate cancer in Japanese.Methods:A total of 15 471 Japanese men participating in the Japan Collaborative Cohort study completed a questionnaire including food intake. Of them, 143 incident prostate cancers were documented. We examined the associations stated above by using Cox proportional hazard model.Results:Vegetable intake was not associated with the risk of prostate cancer, but so was dietary alpha-carotene intake. The multivariable hazard ratio (95%CI) in the secondary highest and highest quintiles of alpha-carotene intake was 0.50 (0.26-0.98) (P=0.043) and 0.46 (0.22-0.97) (P=0.041) (P for trend=0.224), respectively. Beta-carotene intake was not associated with the risk of prostate cancer.Conclusion:Alpha-carotene intake was associated with lower risk of prostate cancer among Japanese.
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U2 - 10.1038/bjc.2013.685
DO - 10.1038/bjc.2013.685
M3 - Article
C2 - 24169341
AN - SCOPUS:84893794047
SN - 0007-0920
VL - 110
SP - 792
EP - 796
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 3
ER -