Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

Le Hoa Nguyen, Shingo Kakeda, Asuka Katsuki, Koichiro Sugimoto, Yuka Otsuka, Issei Ueda, Ryohei Igata, Keita Watanabe, Taro Kishi, Nakao Iwata, Yukunori Korogi, Reiji Yoshimura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-naïve MDD patients. A total of 38 first-episode drug-naïve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging. Blood samples were collected from all the participants for serum VEGF assays and VEGF-related SNPs genotyping. Genotype–diagnosis interactions related to whole-brain cortical thickness and hippocampal subfield volumes were evaluated for the four SNPs. The results revealed a genotype–diagnosis interaction only for rs6921438 (i.e., the MDD patients and HS with the G/G genotype versus the MDD patients and HS with A-carrier genotype) in the subiculum of the left hippocampus (p < 0.05), and not the other SNPs. There was a volume reduction in the left subiculum of G/G genotype patients compared with the other groups. The “hypochondriasis” scores of the HAMD-17 scale were significantly higher in the G/G genotype patients than the A-carrier genotype patients. The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-naïve MDD patients.

Original languageEnglish
Pages (from-to)785-794
Number of pages10
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume269
Issue number7
DOIs
Publication statusPublished - 01-10-2019

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Major Depressive Disorder
Vascular Endothelial Growth Factor A
Single Nucleotide Polymorphism
Brain
Genotype
Genes
Hippocampus
Healthy Volunteers
Therapeutics
Hypochondriasis
Pharmaceutical Preparations
Genome-Wide Association Study
Atrophy
Serum

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

Nguyen, Le Hoa ; Kakeda, Shingo ; Katsuki, Asuka ; Sugimoto, Koichiro ; Otsuka, Yuka ; Ueda, Issei ; Igata, Ryohei ; Watanabe, Keita ; Kishi, Taro ; Iwata, Nakao ; Korogi, Yukunori ; Yoshimura, Reiji. / Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. In: European Archives of Psychiatry and Clinical Neuroscience. 2019 ; Vol. 269, No. 7. pp. 785-794.
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abstract = "Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-na{\"i}ve MDD patients. A total of 38 first-episode drug-na{\"i}ve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging. Blood samples were collected from all the participants for serum VEGF assays and VEGF-related SNPs genotyping. Genotype–diagnosis interactions related to whole-brain cortical thickness and hippocampal subfield volumes were evaluated for the four SNPs. The results revealed a genotype–diagnosis interaction only for rs6921438 (i.e., the MDD patients and HS with the G/G genotype versus the MDD patients and HS with A-carrier genotype) in the subiculum of the left hippocampus (p < 0.05), and not the other SNPs. There was a volume reduction in the left subiculum of G/G genotype patients compared with the other groups. The “hypochondriasis” scores of the HAMD-17 scale were significantly higher in the G/G genotype patients than the A-carrier genotype patients. The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-na{\"i}ve MDD patients.",
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Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. / Nguyen, Le Hoa; Kakeda, Shingo; Katsuki, Asuka; Sugimoto, Koichiro; Otsuka, Yuka; Ueda, Issei; Igata, Ryohei; Watanabe, Keita; Kishi, Taro; Iwata, Nakao; Korogi, Yukunori; Yoshimura, Reiji.

In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 269, No. 7, 01.10.2019, p. 785-794.

Research output: Contribution to journalArticle

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T1 - Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

AU - Nguyen, Le Hoa

AU - Kakeda, Shingo

AU - Katsuki, Asuka

AU - Sugimoto, Koichiro

AU - Otsuka, Yuka

AU - Ueda, Issei

AU - Igata, Ryohei

AU - Watanabe, Keita

AU - Kishi, Taro

AU - Iwata, Nakao

AU - Korogi, Yukunori

AU - Yoshimura, Reiji

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