TY - JOUR
T1 - Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes
AU - Yasuda, Masayuki
AU - Shimura, Masahiko
AU - Kunikata, Hiroshi
AU - Kanazawa, Hiroko
AU - Yasuda, Kanako
AU - Tanaka, Yuji
AU - Konno, Hideyuki
AU - Takahashi, Mai
AU - Kokubun, Taiki
AU - Maruyama, Kazuichi
AU - Sato, Noriko
AU - Kakizaki, Masako
AU - Sato, Mari
AU - Tsuji, Ichiro
AU - Miyata, Toshio
AU - Nakazawa, Toru
N1 - Publisher Copyright:
© 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Abstract Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects the accumulation of advanced glycation end products (AGEs), and the severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Sixty-seven eyes of 67 patients with type 2 diabetes were enrolled. Sixty-seven age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: no DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). SAF was measured with an autofluorescence reader. Results: SAF in the diabetes patients was significantly higher than in the controls (median 2.5 (interquartile range 2.3-2.7) and 1.8 (1.6-2.3) arbitrary unit (AU), respectively, p < 0.001). There was a statistically significant increase in SAF along with the increasing severity of DR (from NDR to NPDR: p = 0.034; NPDR to PDR: p < 0.01). Logistic regression analysis revealed that SAF (OR, 17.2; p < 0.05) was an independent factor indicating the presence of PDR. Conclusions: SAF has an independent relationship with PDR in patients with type 2 diabetes. SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR. SAF may, therefore, be a surrogate marker candidate for the non-invasive evaluation of DR.
AB - Abstract Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects the accumulation of advanced glycation end products (AGEs), and the severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Sixty-seven eyes of 67 patients with type 2 diabetes were enrolled. Sixty-seven age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: no DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). SAF was measured with an autofluorescence reader. Results: SAF in the diabetes patients was significantly higher than in the controls (median 2.5 (interquartile range 2.3-2.7) and 1.8 (1.6-2.3) arbitrary unit (AU), respectively, p < 0.001). There was a statistically significant increase in SAF along with the increasing severity of DR (from NDR to NPDR: p = 0.034; NPDR to PDR: p < 0.01). Logistic regression analysis revealed that SAF (OR, 17.2; p < 0.05) was an independent factor indicating the presence of PDR. Conclusions: SAF has an independent relationship with PDR in patients with type 2 diabetes. SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR. SAF may, therefore, be a surrogate marker candidate for the non-invasive evaluation of DR.
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U2 - 10.3109/02713683.2014.918152
DO - 10.3109/02713683.2014.918152
M3 - Article
C2 - 24871684
AN - SCOPUS:84925355710
SN - 0271-3683
VL - 40
SP - 338
EP - 345
JO - Current Eye Research
JF - Current Eye Research
IS - 3
ER -
