Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes

Masayuki Yasuda, Masahiko Shimura, Hiroshi Kunikata, Hiroko Kanazawa, Kanako Yasuda, Yuji Tanaka, Hideyuki Konno, Mai Takahashi, Taiki Kokubun, Kazuichi Maruyama, Noriko Sato, Masako Kakizaki, Mari Sato, Ichiro Tsuji, Toshio Miyata, Toru Nakazawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Abstract Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects the accumulation of advanced glycation end products (AGEs), and the severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Sixty-seven eyes of 67 patients with type 2 diabetes were enrolled. Sixty-seven age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: no DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). SAF was measured with an autofluorescence reader. Results: SAF in the diabetes patients was significantly higher than in the controls (median 2.5 (interquartile range 2.3-2.7) and 1.8 (1.6-2.3) arbitrary unit (AU), respectively, p < 0.001). There was a statistically significant increase in SAF along with the increasing severity of DR (from NDR to NPDR: p = 0.034; NPDR to PDR: p < 0.01). Logistic regression analysis revealed that SAF (OR, 17.2; p < 0.05) was an independent factor indicating the presence of PDR. Conclusions: SAF has an independent relationship with PDR in patients with type 2 diabetes. SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR. SAF may, therefore, be a surrogate marker candidate for the non-invasive evaluation of DR.

Original languageEnglish
Pages (from-to)338-345
Number of pages8
JournalCurrent Eye Research
Volume40
Issue number3
DOIs
Publication statusPublished - 01-03-2015

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Diabetic Retinopathy
Type 2 Diabetes Mellitus
Skin
Advanced Glycosylation End Products
Biomarkers
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Yasuda, M., Shimura, M., Kunikata, H., Kanazawa, H., Yasuda, K., Tanaka, Y., ... Nakazawa, T. (2015). Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes. Current Eye Research, 40(3), 338-345. https://doi.org/10.3109/02713683.2014.918152
Yasuda, Masayuki ; Shimura, Masahiko ; Kunikata, Hiroshi ; Kanazawa, Hiroko ; Yasuda, Kanako ; Tanaka, Yuji ; Konno, Hideyuki ; Takahashi, Mai ; Kokubun, Taiki ; Maruyama, Kazuichi ; Sato, Noriko ; Kakizaki, Masako ; Sato, Mari ; Tsuji, Ichiro ; Miyata, Toshio ; Nakazawa, Toru. / Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes. In: Current Eye Research. 2015 ; Vol. 40, No. 3. pp. 338-345.
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abstract = "Abstract Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects the accumulation of advanced glycation end products (AGEs), and the severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Sixty-seven eyes of 67 patients with type 2 diabetes were enrolled. Sixty-seven age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: no DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). SAF was measured with an autofluorescence reader. Results: SAF in the diabetes patients was significantly higher than in the controls (median 2.5 (interquartile range 2.3-2.7) and 1.8 (1.6-2.3) arbitrary unit (AU), respectively, p < 0.001). There was a statistically significant increase in SAF along with the increasing severity of DR (from NDR to NPDR: p = 0.034; NPDR to PDR: p < 0.01). Logistic regression analysis revealed that SAF (OR, 17.2; p < 0.05) was an independent factor indicating the presence of PDR. Conclusions: SAF has an independent relationship with PDR in patients with type 2 diabetes. SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR. SAF may, therefore, be a surrogate marker candidate for the non-invasive evaluation of DR.",
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Yasuda, M, Shimura, M, Kunikata, H, Kanazawa, H, Yasuda, K, Tanaka, Y, Konno, H, Takahashi, M, Kokubun, T, Maruyama, K, Sato, N, Kakizaki, M, Sato, M, Tsuji, I, Miyata, T & Nakazawa, T 2015, 'Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes', Current Eye Research, vol. 40, no. 3, pp. 338-345. https://doi.org/10.3109/02713683.2014.918152

Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes. / Yasuda, Masayuki; Shimura, Masahiko; Kunikata, Hiroshi; Kanazawa, Hiroko; Yasuda, Kanako; Tanaka, Yuji; Konno, Hideyuki; Takahashi, Mai; Kokubun, Taiki; Maruyama, Kazuichi; Sato, Noriko; Kakizaki, Masako; Sato, Mari; Tsuji, Ichiro; Miyata, Toshio; Nakazawa, Toru.

In: Current Eye Research, Vol. 40, No. 3, 01.03.2015, p. 338-345.

Research output: Contribution to journalArticle

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T1 - Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes

AU - Yasuda, Masayuki

AU - Shimura, Masahiko

AU - Kunikata, Hiroshi

AU - Kanazawa, Hiroko

AU - Yasuda, Kanako

AU - Tanaka, Yuji

AU - Konno, Hideyuki

AU - Takahashi, Mai

AU - Kokubun, Taiki

AU - Maruyama, Kazuichi

AU - Sato, Noriko

AU - Kakizaki, Masako

AU - Sato, Mari

AU - Tsuji, Ichiro

AU - Miyata, Toshio

AU - Nakazawa, Toru

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Abstract Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects the accumulation of advanced glycation end products (AGEs), and the severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Sixty-seven eyes of 67 patients with type 2 diabetes were enrolled. Sixty-seven age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: no DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). SAF was measured with an autofluorescence reader. Results: SAF in the diabetes patients was significantly higher than in the controls (median 2.5 (interquartile range 2.3-2.7) and 1.8 (1.6-2.3) arbitrary unit (AU), respectively, p < 0.001). There was a statistically significant increase in SAF along with the increasing severity of DR (from NDR to NPDR: p = 0.034; NPDR to PDR: p < 0.01). Logistic regression analysis revealed that SAF (OR, 17.2; p < 0.05) was an independent factor indicating the presence of PDR. Conclusions: SAF has an independent relationship with PDR in patients with type 2 diabetes. SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR. SAF may, therefore, be a surrogate marker candidate for the non-invasive evaluation of DR.

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Yasuda M, Shimura M, Kunikata H, Kanazawa H, Yasuda K, Tanaka Y et al. Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes. Current Eye Research. 2015 Mar 1;40(3):338-345. https://doi.org/10.3109/02713683.2014.918152