Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: The JACC Study

Renzhe Cui, Hiroyasu Iso, Hideaki Toyoshima, Chigusa Date, Akio Yamamoto, Shogo Kikuchi, Takaaki Kondo, Yoshiyuki Watanabe, Akio Koizumi, Yutaka Inaba, Akiko Tamakoshi, Mitsuro Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Haruo Mikami, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Kenji WakaiShinkan Tokudome, Yoshinori Ito, Shuji Hashimoto, Takashi Kawamura, Tsuneharu Miki, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Takashi Shimamoto, Heizo Tanaka

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Background: Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. Methods: We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study. Causes of death were determined based on the International Classification of Disease. Results: There were 487 mortality of stroke and 178 mortality of coronary heart disease. Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. However, compared with women with age at menarche ≤13 years, those with age at menarche ≥17 years tended to have increased risk of mortality from stroke: the multivariable hazard ratio was 1.32 (95% confidence interval [CI]: 0.93-1.87, p = 0.10). Compared with women with age at menopause of ≥49 years, those with age at menopause of <49 years tended to have increased risk of coronary heart disease among women aged 40-64 years; the multivariable hazard ratio was 1.85 (95% CI: 0.92-3.73, p = 0.08). Conclusions: The possible association between early menopause and coronary heart disease among middle-aged women was consistent with the result of observational studies for Caucasian women, and can be explained by a protective effect of endogenous estrogen on the development of atherosclerosis.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalJournal of epidemiology
Volume16
Issue number5
DOIs
Publication statusPublished - 04-09-2006

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Menarche
Menopause
Japan
Cohort Studies
Cardiovascular Diseases
Mortality
Coronary Disease
Stroke
Confidence Intervals
International Classification of Diseases
Observational Studies
Reproduction
Cause of Death
Atherosclerosis
Estrogens

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Cui, Renzhe ; Iso, Hiroyasu ; Toyoshima, Hideaki ; Date, Chigusa ; Yamamoto, Akio ; Kikuchi, Shogo ; Kondo, Takaaki ; Watanabe, Yoshiyuki ; Koizumi, Akio ; Inaba, Yutaka ; Tamakoshi, Akiko ; Mori, Mitsuro ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Mikami, Haruo ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Wakai, Kenji ; Tokudome, Shinkan ; Ito, Yoshinori ; Hashimoto, Shuji ; Kawamura, Takashi ; Miki, Tsuneharu ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo ; Shimamoto, Takashi ; Tanaka, Heizo. / Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women : The JACC Study. In: Journal of epidemiology. 2006 ; Vol. 16, No. 5. pp. 177-184.
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title = "Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: The JACC Study",
abstract = "Background: Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. Methods: We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study. Causes of death were determined based on the International Classification of Disease. Results: There were 487 mortality of stroke and 178 mortality of coronary heart disease. Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. However, compared with women with age at menarche ≤13 years, those with age at menarche ≥17 years tended to have increased risk of mortality from stroke: the multivariable hazard ratio was 1.32 (95{\%} confidence interval [CI]: 0.93-1.87, p = 0.10). Compared with women with age at menopause of ≥49 years, those with age at menopause of <49 years tended to have increased risk of coronary heart disease among women aged 40-64 years; the multivariable hazard ratio was 1.85 (95{\%} CI: 0.92-3.73, p = 0.08). Conclusions: The possible association between early menopause and coronary heart disease among middle-aged women was consistent with the result of observational studies for Caucasian women, and can be explained by a protective effect of endogenous estrogen on the development of atherosclerosis.",
author = "Renzhe Cui and Hiroyasu Iso and Hideaki Toyoshima and Chigusa Date and Akio Yamamoto and Shogo Kikuchi and Takaaki Kondo and Yoshiyuki Watanabe and Akio Koizumi and Yutaka Inaba and Akiko Tamakoshi and Mitsuro Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Haruo Mikami and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Kenji Wakai and Shinkan Tokudome and Yoshinori Ito and Shuji Hashimoto and Takashi Kawamura and Tsuneharu Miki and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima and Takashi Shimamoto and Heizo Tanaka",
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Cui, R, Iso, H, Toyoshima, H, Date, C, Yamamoto, A, Kikuchi, S, Kondo, T, Watanabe, Y, Koizumi, A, Inaba, Y, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Mikami, H, Hoshiyama, Y, Suzuki, H, Shimizu, H, Wakai, K, Tokudome, S, Ito, Y, Hashimoto, S, Kawamura, T, Miki, T, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T, Tajima, K, Shimamoto, T & Tanaka, H 2006, 'Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: The JACC Study', Journal of epidemiology, vol. 16, no. 5, pp. 177-184. https://doi.org/10.2188/jea.16.177

Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women : The JACC Study. / Cui, Renzhe; Iso, Hiroyasu; Toyoshima, Hideaki; Date, Chigusa; Yamamoto, Akio; Kikuchi, Shogo; Kondo, Takaaki; Watanabe, Yoshiyuki; Koizumi, Akio; Inaba, Yutaka; Tamakoshi, Akiko; Mori, Mitsuro; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Mikami, Haruo; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Wakai, Kenji; Tokudome, Shinkan; Ito, Yoshinori; Hashimoto, Shuji; Kawamura, Takashi; Miki, Tsuneharu; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo; Shimamoto, Takashi; Tanaka, Heizo.

In: Journal of epidemiology, Vol. 16, No. 5, 04.09.2006, p. 177-184.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women

T2 - The JACC Study

AU - Cui, Renzhe

AU - Iso, Hiroyasu

AU - Toyoshima, Hideaki

AU - Date, Chigusa

AU - Yamamoto, Akio

AU - Kikuchi, Shogo

AU - Kondo, Takaaki

AU - Watanabe, Yoshiyuki

AU - Koizumi, Akio

AU - Inaba, Yutaka

AU - Tamakoshi, Akiko

AU - Mori, Mitsuro

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Mikami, Haruo

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

AU - Shimamoto, Takashi

AU - Tanaka, Heizo

PY - 2006/9/4

Y1 - 2006/9/4

N2 - Background: Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. Methods: We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study. Causes of death were determined based on the International Classification of Disease. Results: There were 487 mortality of stroke and 178 mortality of coronary heart disease. Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. However, compared with women with age at menarche ≤13 years, those with age at menarche ≥17 years tended to have increased risk of mortality from stroke: the multivariable hazard ratio was 1.32 (95% confidence interval [CI]: 0.93-1.87, p = 0.10). Compared with women with age at menopause of ≥49 years, those with age at menopause of <49 years tended to have increased risk of coronary heart disease among women aged 40-64 years; the multivariable hazard ratio was 1.85 (95% CI: 0.92-3.73, p = 0.08). Conclusions: The possible association between early menopause and coronary heart disease among middle-aged women was consistent with the result of observational studies for Caucasian women, and can be explained by a protective effect of endogenous estrogen on the development of atherosclerosis.

AB - Background: Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. Methods: We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study. Causes of death were determined based on the International Classification of Disease. Results: There were 487 mortality of stroke and 178 mortality of coronary heart disease. Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. However, compared with women with age at menarche ≤13 years, those with age at menarche ≥17 years tended to have increased risk of mortality from stroke: the multivariable hazard ratio was 1.32 (95% confidence interval [CI]: 0.93-1.87, p = 0.10). Compared with women with age at menopause of ≥49 years, those with age at menopause of <49 years tended to have increased risk of coronary heart disease among women aged 40-64 years; the multivariable hazard ratio was 1.85 (95% CI: 0.92-3.73, p = 0.08). Conclusions: The possible association between early menopause and coronary heart disease among middle-aged women was consistent with the result of observational studies for Caucasian women, and can be explained by a protective effect of endogenous estrogen on the development of atherosclerosis.

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