Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases.

Yuki Murakami, Masato Hoshi, Yukio Imamura, Yuko Arioka, Yasuko Yamamoto, Kuniaki Saito

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases. In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented. Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed. This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.

Original languageEnglish
Number of pages1
JournalUnknown Journal
Volume2013
Publication statusPublished - 2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology

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