TY - JOUR
T1 - Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases
T2 - potential role in macrophage-mediated inflammatory diseases.
AU - Murakami, Yuki
AU - Hoshi, Masato
AU - Imamura, Yukio
AU - Arioka, Yuko
AU - Yamamoto, Yasuko
AU - Saito, Kuniaki
PY - 2013
Y1 - 2013
N2 - Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases. In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented. Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed. This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.
AB - Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases. In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented. Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed. This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.
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U2 - 10.1155/2013/391984
DO - 10.1155/2013/391984
M3 - Review article
C2 - 23476103
AN - SCOPUS:84882260715
VL - 2013
SP - 391984
JO - Unknown Journal
JF - Unknown Journal
ER -
