Remodeling of heat-treated cortical bone allografts for posterior lumbar interbody fusion: Serial 10-year follow-up

Koichi Muramatsu, Yudo Hachiya, Hiroyuki Izawa, Harumoto Yamada

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We have selected heat-treated bone allografts as the graft material since the Tokai Bone Bank, the first regional bone bank in Japan, was established in 1992. In this study, we examined changes in bone mineral density (BMD), and morphology observed by magnetic resonance imaging (MRI), and histological findings of bone grafts in cases followed up for 7-10 years after bone grafting to grasp the remodeling of heat-treated cortical bone allografts for posterior lumber interbody fusion (PLIF). BMD of bone grafts was reduced by half at 10 years after grafting. MRI revealed that bone grafts were indistinguishable initially in only 22.2% of cases, whereas after a lengthy period of 10 years distinguishable in many cases. Histologically, new bone formation at the graft-host interface was observed earlier, at 1 year after grafting, than that at the periphery of canals in the specimens. The laminated structure of the cortical bone eroded over time, and fragmented bone trabeculae were observed in the specimens at 8 years or longer after grafting, though necrotic bone still remained in some sites.

Original languageEnglish
Pages (from-to)529-536
Number of pages8
JournalCell and Tissue Banking
Issue number4
Publication statusPublished - 01-12-2012


All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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