Remodeling of heat-treated cortical bone allografts for posterior lumbar interbody fusion: Serial 10-year follow-up

Koichi Muramatsu, Yudo Hachiya, Hiroyuki Izawa, Harumoto Yamada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have selected heat-treated bone allografts as the graft material since the Tokai Bone Bank, the first regional bone bank in Japan, was established in 1992. In this study, we examined changes in bone mineral density (BMD), and morphology observed by magnetic resonance imaging (MRI), and histological findings of bone grafts in cases followed up for 7-10 years after bone grafting to grasp the remodeling of heat-treated cortical bone allografts for posterior lumber interbody fusion (PLIF). BMD of bone grafts was reduced by half at 10 years after grafting. MRI revealed that bone grafts were indistinguishable initially in only 22.2% of cases, whereas after a lengthy period of 10 years distinguishable in many cases. Histologically, new bone formation at the graft-host interface was observed earlier, at 1 year after grafting, than that at the periphery of canals in the specimens. The laminated structure of the cortical bone eroded over time, and fragmented bone trabeculae were observed in the specimens at 8 years or longer after grafting, though necrotic bone still remained in some sites.

Original languageEnglish
Pages (from-to)529-536
Number of pages8
JournalCell and Tissue Banking
Volume13
Issue number4
DOIs
Publication statusPublished - 01-12-2012

Fingerprint

Allografts
Bone
Fusion reactions
Hot Temperature
Transplants
Bone and Bones
Bone Banks
Bone Transplantation
Bone Density
Grafts
Magnetic Resonance Imaging
Osteogenesis
Japan
Magnetic resonance
Cortical Bone
Minerals
Imaging techniques
Lumber
Canals

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

@article{de625bdc432545aa96d1fb66b8266c39,
title = "Remodeling of heat-treated cortical bone allografts for posterior lumbar interbody fusion: Serial 10-year follow-up",
abstract = "We have selected heat-treated bone allografts as the graft material since the Tokai Bone Bank, the first regional bone bank in Japan, was established in 1992. In this study, we examined changes in bone mineral density (BMD), and morphology observed by magnetic resonance imaging (MRI), and histological findings of bone grafts in cases followed up for 7-10 years after bone grafting to grasp the remodeling of heat-treated cortical bone allografts for posterior lumber interbody fusion (PLIF). BMD of bone grafts was reduced by half at 10 years after grafting. MRI revealed that bone grafts were indistinguishable initially in only 22.2{\%} of cases, whereas after a lengthy period of 10 years distinguishable in many cases. Histologically, new bone formation at the graft-host interface was observed earlier, at 1 year after grafting, than that at the periphery of canals in the specimens. The laminated structure of the cortical bone eroded over time, and fragmented bone trabeculae were observed in the specimens at 8 years or longer after grafting, though necrotic bone still remained in some sites.",
author = "Koichi Muramatsu and Yudo Hachiya and Hiroyuki Izawa and Harumoto Yamada",
year = "2012",
month = "12",
day = "1",
doi = "10.1007/s10561-011-9268-y",
language = "English",
volume = "13",
pages = "529--536",
journal = "Cell and Tissue Banking",
issn = "1389-9333",
publisher = "Springer Netherlands",
number = "4",

}

Remodeling of heat-treated cortical bone allografts for posterior lumbar interbody fusion : Serial 10-year follow-up. / Muramatsu, Koichi; Hachiya, Yudo; Izawa, Hiroyuki; Yamada, Harumoto.

In: Cell and Tissue Banking, Vol. 13, No. 4, 01.12.2012, p. 529-536.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Remodeling of heat-treated cortical bone allografts for posterior lumbar interbody fusion

T2 - Serial 10-year follow-up

AU - Muramatsu, Koichi

AU - Hachiya, Yudo

AU - Izawa, Hiroyuki

AU - Yamada, Harumoto

PY - 2012/12/1

Y1 - 2012/12/1

N2 - We have selected heat-treated bone allografts as the graft material since the Tokai Bone Bank, the first regional bone bank in Japan, was established in 1992. In this study, we examined changes in bone mineral density (BMD), and morphology observed by magnetic resonance imaging (MRI), and histological findings of bone grafts in cases followed up for 7-10 years after bone grafting to grasp the remodeling of heat-treated cortical bone allografts for posterior lumber interbody fusion (PLIF). BMD of bone grafts was reduced by half at 10 years after grafting. MRI revealed that bone grafts were indistinguishable initially in only 22.2% of cases, whereas after a lengthy period of 10 years distinguishable in many cases. Histologically, new bone formation at the graft-host interface was observed earlier, at 1 year after grafting, than that at the periphery of canals in the specimens. The laminated structure of the cortical bone eroded over time, and fragmented bone trabeculae were observed in the specimens at 8 years or longer after grafting, though necrotic bone still remained in some sites.

AB - We have selected heat-treated bone allografts as the graft material since the Tokai Bone Bank, the first regional bone bank in Japan, was established in 1992. In this study, we examined changes in bone mineral density (BMD), and morphology observed by magnetic resonance imaging (MRI), and histological findings of bone grafts in cases followed up for 7-10 years after bone grafting to grasp the remodeling of heat-treated cortical bone allografts for posterior lumber interbody fusion (PLIF). BMD of bone grafts was reduced by half at 10 years after grafting. MRI revealed that bone grafts were indistinguishable initially in only 22.2% of cases, whereas after a lengthy period of 10 years distinguishable in many cases. Histologically, new bone formation at the graft-host interface was observed earlier, at 1 year after grafting, than that at the periphery of canals in the specimens. The laminated structure of the cortical bone eroded over time, and fragmented bone trabeculae were observed in the specimens at 8 years or longer after grafting, though necrotic bone still remained in some sites.

UR - http://www.scopus.com/inward/record.url?scp=84870279528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870279528&partnerID=8YFLogxK

U2 - 10.1007/s10561-011-9268-y

DO - 10.1007/s10561-011-9268-y

M3 - Article

C2 - 21773718

AN - SCOPUS:84870279528

VL - 13

SP - 529

EP - 536

JO - Cell and Tissue Banking

JF - Cell and Tissue Banking

SN - 1389-9333

IS - 4

ER -