Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: A case report

Nobuya Kitaguchi; Takashi Kato; Shinji Matsunaga; Kyoko Hirano; Kaori Iwata; Kazunori Kawaguchi; Kiyoshi Fujita; Hajime Takechi; Midori Hasegawa; Yukio Yuzawa; Kengo Ito

doi:10.2147/NDT.S186118

Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: A case report

Nobuya Kitaguchi, Takashi Kato, Shinji Matsunaga, Kyoko Hirano, Kaori Iwata, Kazunori Kawaguchi, Kiyoshi Fujita, Hajime Takechi, Midori Hasegawa, Yukio Yuzawa, Kengo Ito

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11 Citations (Scopus)

Abstract

The accumulation of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer’s disease (AD). Extracorporeal blood Aβ removal system (E-BARS) has been under development as a tool for enhancing the clearance of Aβ from the brain. Previously, we revealed that dialyzers remove blood Aβs effectively, evoking substantial Aβ influx into the blood during hemodialysis sessions as one form of blood Aβ removal by E-BARS, and that postmortem brains of hemodialysis patients exhibited lower Aβ accumulation. Here, we present a case report of a 77-year-old male patient with end-stage renal failure whose Aβ accumulation in the brain declined by initiating and continuing hemodialysis for 6 months. This report suggests that blood Aβ removal by E-BARS could be an effective therapeutic method for AD.

Original language	English
Pages (from-to)	2931-2937
Number of pages	7
Journal	Neuropsychiatric Disease and Treatment
Volume	14
DOIs	https://doi.org/10.2147/NDT.S186118
Publication status	Published - 2018

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/NDT.S186118

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title = "Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: A case report",

abstract = "The accumulation of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer{\textquoteright}s disease (AD). Extracorporeal blood Aβ removal system (E-BARS) has been under development as a tool for enhancing the clearance of Aβ from the brain. Previously, we revealed that dialyzers remove blood Aβs effectively, evoking substantial Aβ influx into the blood during hemodialysis sessions as one form of blood Aβ removal by E-BARS, and that postmortem brains of hemodialysis patients exhibited lower Aβ accumulation. Here, we present a case report of a 77-year-old male patient with end-stage renal failure whose Aβ accumulation in the brain declined by initiating and continuing hemodialysis for 6 months. This report suggests that blood Aβ removal by E-BARS could be an effective therapeutic method for AD.",

keywords = "Alzheimer{\textquoteright}s disease, Amyloid-β, Aβ, Blood Aβ removal, Blood purification, E-BARS, Extracorporeal blood Aβ removal system, PiB/PET",

author = "Nobuya Kitaguchi and Takashi Kato and Shinji Matsunaga and Kyoko Hirano and Kaori Iwata and Kazunori Kawaguchi and Kiyoshi Fujita and Hajime Takechi and Midori Hasegawa and Yukio Yuzawa and Kengo Ito",

note = "Publisher Copyright: {\textcopyright} 2018 Kitaguchi et al.",

year = "2018",

doi = "10.2147/NDT.S186118",

language = "English",

volume = "14",

pages = "2931--2937",

journal = "Neuropsychiatric Disease and Treatment",

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T1 - Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging

T2 - A case report

AU - Kitaguchi, Nobuya

AU - Kato, Takashi

AU - Matsunaga, Shinji

AU - Hirano, Kyoko

AU - Iwata, Kaori

AU - Kawaguchi, Kazunori

AU - Fujita, Kiyoshi

AU - Takechi, Hajime

AU - Hasegawa, Midori

AU - Yuzawa, Yukio

AU - Ito, Kengo

PY - 2018

Y1 - 2018

N2 - The accumulation of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer’s disease (AD). Extracorporeal blood Aβ removal system (E-BARS) has been under development as a tool for enhancing the clearance of Aβ from the brain. Previously, we revealed that dialyzers remove blood Aβs effectively, evoking substantial Aβ influx into the blood during hemodialysis sessions as one form of blood Aβ removal by E-BARS, and that postmortem brains of hemodialysis patients exhibited lower Aβ accumulation. Here, we present a case report of a 77-year-old male patient with end-stage renal failure whose Aβ accumulation in the brain declined by initiating and continuing hemodialysis for 6 months. This report suggests that blood Aβ removal by E-BARS could be an effective therapeutic method for AD.

AB - The accumulation of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer’s disease (AD). Extracorporeal blood Aβ removal system (E-BARS) has been under development as a tool for enhancing the clearance of Aβ from the brain. Previously, we revealed that dialyzers remove blood Aβs effectively, evoking substantial Aβ influx into the blood during hemodialysis sessions as one form of blood Aβ removal by E-BARS, and that postmortem brains of hemodialysis patients exhibited lower Aβ accumulation. Here, we present a case report of a 77-year-old male patient with end-stage renal failure whose Aβ accumulation in the brain declined by initiating and continuing hemodialysis for 6 months. This report suggests that blood Aβ removal by E-BARS could be an effective therapeutic method for AD.

KW - Alzheimer’s disease

KW - Amyloid-β

KW - Aβ

KW - Blood Aβ removal

KW - Blood purification

KW - E-BARS

KW - Extracorporeal blood Aβ removal system

KW - PiB/PET

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M3 - Article

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SN - 1176-6328

VL - 14

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JO - Neuropsychiatric Disease and Treatment

JF - Neuropsychiatric Disease and Treatment

ER -

Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: A case report

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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