Renal impairment after laparoscopic radical nephrectomy affects hypoglycaemic therapy

T. Mizuno, K. Ito, Y. Miyagawa, K. Kimura, Y. Suzuki, M. Mizuno, Y. Ito, Y. Funahashi, R. Hattori, M. Gotoh, Y. Noda, K. Yamada

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

What is known and Objective: Renal impairment is unavoidable after laparoscopic radical nephrectomy (LRN) and is an important consideration for drug therapy. It is possible that the renal impairment after LRN causes adverse reactions following reduced elimination of some renally excreted drugs, such as hypoglycaemic drugs. However, there are few studies of renal function in patients with diabetes mellitus (DM) in the first week after LRN. The purpose of this study was to examine whether renal impairment after LRN affected glycaemic control. We assessed pre- and postoperative renal function of DM patients and examined whether re-administration of hypoglycaemic drugs in the first week after LRN causes episodes of hypoglycaemia. Methods: Renal carcinoma patients undergoing LRN in Nagoya University Hospital from January 2007 to December 2009 were identified in a retrospective cohort study design. Patients were divided into non-DM (n = 60) and DM (n = 14) groups. Results and discussion: There were significant differences in postoperative estimated glomerular filtration rate values between the non-DM and DM groups. Four of nine patients (44%) experienced hypoglycaemia induced by re-administration of hypoglycaemic drugs, namely, sulfonylureas. What is new and Conclusion: In the present study, we found the first evidence that renal impairment in the first week after LRN was a risk factor of hypoglycaemia. To prevent hypoglycaemia after LRN, assessment of renal function and the use of insulin therapy are important.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJournal of Clinical Pharmacy and Therapeutics
Volume37
Issue number1
DOIs
Publication statusPublished - 02-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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