Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus

M. Yamaguchi; T. Suzuki; T. Seki; T. Namba; R. Juan; H. Arai; T. Hori; T. Asada

doi:10.1196/annals.1316.043

Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus

M. Yamaguchi, T. Suzuki, T. Seki, T. Namba, R. Juan, H. Arai, T. Hori, T. Asada

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

Cocaine HCl (20 mg/kg) was administered to adult male rats to investigate the effects of cocaine on neurogenesis in the hippocampus. Proliferation of granule cells in the dentate gyrus was measured by in vivo labeling with 5-bromo-2′-deoxyuridine (BrdU). Rats that received repetitive cocaine treatment for 14 days showed 26% fewer BrdU-positive cells relative to control rats, while no difference was observed in the rats that received a single injection of cocaine. Differentiation of newly born cells was not influenced. The present experiment is the first to demonstrate the influence of cocaine on hippocampal neurogenesis. These data suggest that the regulation of hippocampal neurogenesis may be involved in the emergence of certain symptoms of cocaine addiction, such as cognitive impairment and behavioral sensitization.

Original language	English
Pages (from-to)	351-362
Number of pages	12
Journal	Annals of the New York Academy of Sciences
Volume	1025
DOIs	https://doi.org/10.1196/annals.1316.043
Publication status	Published - 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

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10.1196/annals.1316.043

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title = "Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus",

abstract = "Cocaine HCl (20 mg/kg) was administered to adult male rats to investigate the effects of cocaine on neurogenesis in the hippocampus. Proliferation of granule cells in the dentate gyrus was measured by in vivo labeling with 5-bromo-2′-deoxyuridine (BrdU). Rats that received repetitive cocaine treatment for 14 days showed 26\% fewer BrdU-positive cells relative to control rats, while no difference was observed in the rats that received a single injection of cocaine. Differentiation of newly born cells was not influenced. The present experiment is the first to demonstrate the influence of cocaine on hippocampal neurogenesis. These data suggest that the regulation of hippocampal neurogenesis may be involved in the emergence of certain symptoms of cocaine addiction, such as cognitive impairment and behavioral sensitization.",

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T1 - Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus

AU - Yamaguchi, M.

AU - Suzuki, T.

AU - Seki, T.

AU - Namba, T.

AU - Juan, R.

AU - Arai, H.

AU - Hori, T.

AU - Asada, T.

PY - 2004

Y1 - 2004

N2 - Cocaine HCl (20 mg/kg) was administered to adult male rats to investigate the effects of cocaine on neurogenesis in the hippocampus. Proliferation of granule cells in the dentate gyrus was measured by in vivo labeling with 5-bromo-2′-deoxyuridine (BrdU). Rats that received repetitive cocaine treatment for 14 days showed 26% fewer BrdU-positive cells relative to control rats, while no difference was observed in the rats that received a single injection of cocaine. Differentiation of newly born cells was not influenced. The present experiment is the first to demonstrate the influence of cocaine on hippocampal neurogenesis. These data suggest that the regulation of hippocampal neurogenesis may be involved in the emergence of certain symptoms of cocaine addiction, such as cognitive impairment and behavioral sensitization.

AB - Cocaine HCl (20 mg/kg) was administered to adult male rats to investigate the effects of cocaine on neurogenesis in the hippocampus. Proliferation of granule cells in the dentate gyrus was measured by in vivo labeling with 5-bromo-2′-deoxyuridine (BrdU). Rats that received repetitive cocaine treatment for 14 days showed 26% fewer BrdU-positive cells relative to control rats, while no difference was observed in the rats that received a single injection of cocaine. Differentiation of newly born cells was not influenced. The present experiment is the first to demonstrate the influence of cocaine on hippocampal neurogenesis. These data suggest that the regulation of hippocampal neurogenesis may be involved in the emergence of certain symptoms of cocaine addiction, such as cognitive impairment and behavioral sensitization.

KW - Behavioral sensitization

KW - Cocaine

KW - Hippocampal neurogenesis

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

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Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus

Abstract

All Science Journal Classification (ASJC) codes

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