Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians

Aritoshi Iida, Atsushi Takahashi, Min Deng, Yun Zhang, Jing Wang, Naoki Atsuta, Fumiaki Tanaka, Tetsumasa Kamei, Motoki Sano, Shuichi Oshima, Torao Tokuda, Mitsuya Morita, Chizuru Akimoto, Masahiro Nakajima, Michiaki Kubo, Naoyuki Kamatani, Imaharu Nakano, Gen Sobue, Yusuke Nakamura, Dongsheng FanShiro Ikegawa

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23 Citations (Scopus)

Abstract

We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.

Original languageEnglish
Pages (from-to)757.e13-757.e14
JournalNeurobiology of Aging
Volume32
Issue number4
DOIs
Publication statusPublished - 04-2011

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Iida, A., Takahashi, A., Deng, M., Zhang, Y., Wang, J., Atsuta, N., Tanaka, F., Kamei, T., Sano, M., Oshima, S., Tokuda, T., Morita, M., Akimoto, C., Nakajima, M., Kubo, M., Kamatani, N., Nakano, I., Sobue, G., Nakamura, Y., ... Ikegawa, S. (2011). Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. Neurobiology of Aging, 32(4), 757.e13-757.e14. https://doi.org/10.1016/j.neurobiolaging.2010.12.011