Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians

Aritoshi Iida, Atsushi Takahashi, Min Deng, Yun Zhang, Jing Wang, Naoki Atsuta, Fumiaki Tanaka, Tetsumasa Kamei, Motoki Sano, Shuichi Oshima, Torao Tokuda, Mitsuya Morita, Chizuru Akimoto, Masahiro Nakajima, Michiaki Kubo, Naoyuki Kamatani, Imaharu Nakano, Gen Sobue, Yusuke Nakamura, Dongsheng Fan & 1 others Shiro Ikegawa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.

Original languageEnglish
Pages (from-to)757.e13-757.e14
JournalNeurobiology of Aging
Volume32
Issue number4
DOIs
Publication statusPublished - 01-01-2011

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Amyotrophic Lateral Sclerosis
Single Nucleotide Polymorphism
Odds Ratio
Confidence Intervals
Amyotrophic lateral sclerosis 1

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Iida, A., Takahashi, A., Deng, M., Zhang, Y., Wang, J., Atsuta, N., ... Ikegawa, S. (2011). Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. Neurobiology of Aging, 32(4), 757.e13-757.e14. https://doi.org/10.1016/j.neurobiolaging.2010.12.011
Iida, Aritoshi ; Takahashi, Atsushi ; Deng, Min ; Zhang, Yun ; Wang, Jing ; Atsuta, Naoki ; Tanaka, Fumiaki ; Kamei, Tetsumasa ; Sano, Motoki ; Oshima, Shuichi ; Tokuda, Torao ; Morita, Mitsuya ; Akimoto, Chizuru ; Nakajima, Masahiro ; Kubo, Michiaki ; Kamatani, Naoyuki ; Nakano, Imaharu ; Sobue, Gen ; Nakamura, Yusuke ; Fan, Dongsheng ; Ikegawa, Shiro. / Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 4. pp. 757.e13-757.e14.
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title = "Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians",
abstract = "We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95{\%} confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95{\%} CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.",
author = "Aritoshi Iida and Atsushi Takahashi and Min Deng and Yun Zhang and Jing Wang and Naoki Atsuta and Fumiaki Tanaka and Tetsumasa Kamei and Motoki Sano and Shuichi Oshima and Torao Tokuda and Mitsuya Morita and Chizuru Akimoto and Masahiro Nakajima and Michiaki Kubo and Naoyuki Kamatani and Imaharu Nakano and Gen Sobue and Yusuke Nakamura and Dongsheng Fan and Shiro Ikegawa",
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Iida, A, Takahashi, A, Deng, M, Zhang, Y, Wang, J, Atsuta, N, Tanaka, F, Kamei, T, Sano, M, Oshima, S, Tokuda, T, Morita, M, Akimoto, C, Nakajima, M, Kubo, M, Kamatani, N, Nakano, I, Sobue, G, Nakamura, Y, Fan, D & Ikegawa, S 2011, 'Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians', Neurobiology of Aging, vol. 32, no. 4, pp. 757.e13-757.e14. https://doi.org/10.1016/j.neurobiolaging.2010.12.011

Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. / Iida, Aritoshi; Takahashi, Atsushi; Deng, Min; Zhang, Yun; Wang, Jing; Atsuta, Naoki; Tanaka, Fumiaki; Kamei, Tetsumasa; Sano, Motoki; Oshima, Shuichi; Tokuda, Torao; Morita, Mitsuya; Akimoto, Chizuru; Nakajima, Masahiro; Kubo, Michiaki; Kamatani, Naoyuki; Nakano, Imaharu; Sobue, Gen; Nakamura, Yusuke; Fan, Dongsheng; Ikegawa, Shiro.

In: Neurobiology of Aging, Vol. 32, No. 4, 01.01.2011, p. 757.e13-757.e14.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians

AU - Iida, Aritoshi

AU - Takahashi, Atsushi

AU - Deng, Min

AU - Zhang, Yun

AU - Wang, Jing

AU - Atsuta, Naoki

AU - Tanaka, Fumiaki

AU - Kamei, Tetsumasa

AU - Sano, Motoki

AU - Oshima, Shuichi

AU - Tokuda, Torao

AU - Morita, Mitsuya

AU - Akimoto, Chizuru

AU - Nakajima, Masahiro

AU - Kubo, Michiaki

AU - Kamatani, Naoyuki

AU - Nakano, Imaharu

AU - Sobue, Gen

AU - Nakamura, Yusuke

AU - Fan, Dongsheng

AU - Ikegawa, Shiro

PY - 2011/1/1

Y1 - 2011/1/1

N2 - We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.

AB - We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.

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U2 - 10.1016/j.neurobiolaging.2010.12.011

DO - 10.1016/j.neurobiolaging.2010.12.011

M3 - Article

VL - 32

SP - 757.e13-757.e14

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 4

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