Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies.

Hiroshi Nishio, Takuma Fujii, Juri Sugiyama, Naoaki Kuji, Mamoru Tanaka, Toshio Hamatani, Kei Miyakoshi, Kazuhiro Minegishi, Hiroshi Tsuda, Takashi Iwata, Kyoko Tanaka, Takeshi Fukuchi, Yuji Takehara, Yasunori Yoshimura, Daisuke Aoki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

What are the reproductive and obstetric outcomes in patients undergoing radical abdominal trachelectomy (RAT) for early-stage cervical cancer? When RAT was performed before a pregnancy achieved with fertility treatments, pregnancy rate of 36.2% was obtained and 71.4% of these women gave birth at ≥ 32 weeks of gestation. Reproductive and obstetric outcomes after radical vaginal trachelectomy (RVT) are well documented; however, these outcomes after RAT have not been well studied. This is a retrospective cohort study of patients at a single institution who underwent RAT and became pregnant. Reproductive and obstetric outcomes of 114 patients who had undergone RAT from September 2002 to December 2010 were investigated. Women of reproductive age with early-stage cervical cancer who wished to preserve their fertility were documented. Patients' median age was 33 years (25-40 years). A total of 31 pregnancies were achieved in 25 patients and 6 patients had 2 pregnancies. Eighteen of 25 patients (72.0%) had infertility problems; 17 patients conceived with IVF-embryo transfer and 1 patient with intrauterine insemination. The pregnancy rate among patients who wished to conceive was 36.2% (25/69). Among 31 pregnancies in 25 patients, 4 patients had first trimester miscarriage and 1 patient had second trimester miscarriage. Excluding the five patients who miscarried and the five ongoing pregnancies, all the 21 patients had deliveries by Cesarean section. Four patients had a preterm birth in the second trimester and 17 patients delivered in the third trimester. Of the 17 pregnancies that reached the third trimester, 2 (11.8%) were preterm births between 29 and 32 weeks, 11 (64.7%) were delivered between 32 and 37 weeks and 4 (23.5%) at ≥ 37 weeks of gestation. Because of the retrospective data collection, not all pregnancies may have been recorded. Prospective multicenter studies are needed to determine if the results shown in this retrospective cohort can be generalized to all patients with early-stage cervical cancer who wish to undergo the fertility-sparing RAT procedure.

Original languageEnglish
Pages (from-to)1793-1798
Number of pages6
JournalHuman reproduction (Oxford, England)
Volume28
Issue number7
DOIs
Publication statusPublished - 01-01-2013
Externally publishedYes

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Uterine Cervical Neoplasms
Obstetrics
Pregnancy
Fertility
Trachelectomy
Premature Birth
Third Pregnancy Trimester
Second Pregnancy Trimester
Spontaneous Abortion
Pregnancy Rate
Insemination
Embryo Transfer
First Pregnancy Trimester
Cesarean Section
Infertility
Multicenter Studies

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Nishio, Hiroshi ; Fujii, Takuma ; Sugiyama, Juri ; Kuji, Naoaki ; Tanaka, Mamoru ; Hamatani, Toshio ; Miyakoshi, Kei ; Minegishi, Kazuhiro ; Tsuda, Hiroshi ; Iwata, Takashi ; Tanaka, Kyoko ; Fukuchi, Takeshi ; Takehara, Yuji ; Yoshimura, Yasunori ; Aoki, Daisuke. / Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies. In: Human reproduction (Oxford, England). 2013 ; Vol. 28, No. 7. pp. 1793-1798.
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abstract = "What are the reproductive and obstetric outcomes in patients undergoing radical abdominal trachelectomy (RAT) for early-stage cervical cancer? When RAT was performed before a pregnancy achieved with fertility treatments, pregnancy rate of 36.2{\%} was obtained and 71.4{\%} of these women gave birth at ≥ 32 weeks of gestation. Reproductive and obstetric outcomes after radical vaginal trachelectomy (RVT) are well documented; however, these outcomes after RAT have not been well studied. This is a retrospective cohort study of patients at a single institution who underwent RAT and became pregnant. Reproductive and obstetric outcomes of 114 patients who had undergone RAT from September 2002 to December 2010 were investigated. Women of reproductive age with early-stage cervical cancer who wished to preserve their fertility were documented. Patients' median age was 33 years (25-40 years). A total of 31 pregnancies were achieved in 25 patients and 6 patients had 2 pregnancies. Eighteen of 25 patients (72.0{\%}) had infertility problems; 17 patients conceived with IVF-embryo transfer and 1 patient with intrauterine insemination. The pregnancy rate among patients who wished to conceive was 36.2{\%} (25/69). Among 31 pregnancies in 25 patients, 4 patients had first trimester miscarriage and 1 patient had second trimester miscarriage. Excluding the five patients who miscarried and the five ongoing pregnancies, all the 21 patients had deliveries by Cesarean section. Four patients had a preterm birth in the second trimester and 17 patients delivered in the third trimester. Of the 17 pregnancies that reached the third trimester, 2 (11.8{\%}) were preterm births between 29 and 32 weeks, 11 (64.7{\%}) were delivered between 32 and 37 weeks and 4 (23.5{\%}) at ≥ 37 weeks of gestation. Because of the retrospective data collection, not all pregnancies may have been recorded. Prospective multicenter studies are needed to determine if the results shown in this retrospective cohort can be generalized to all patients with early-stage cervical cancer who wish to undergo the fertility-sparing RAT procedure.",
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Nishio, H, Fujii, T, Sugiyama, J, Kuji, N, Tanaka, M, Hamatani, T, Miyakoshi, K, Minegishi, K, Tsuda, H, Iwata, T, Tanaka, K, Fukuchi, T, Takehara, Y, Yoshimura, Y & Aoki, D 2013, 'Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies.', Human reproduction (Oxford, England), vol. 28, no. 7, pp. 1793-1798. https://doi.org/10.1093/humrep/det118

Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies. / Nishio, Hiroshi; Fujii, Takuma; Sugiyama, Juri; Kuji, Naoaki; Tanaka, Mamoru; Hamatani, Toshio; Miyakoshi, Kei; Minegishi, Kazuhiro; Tsuda, Hiroshi; Iwata, Takashi; Tanaka, Kyoko; Fukuchi, Takeshi; Takehara, Yuji; Yoshimura, Yasunori; Aoki, Daisuke.

In: Human reproduction (Oxford, England), Vol. 28, No. 7, 01.01.2013, p. 1793-1798.

Research output: Contribution to journalArticle

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T1 - Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies.

AU - Nishio, Hiroshi

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AU - Tanaka, Mamoru

AU - Hamatani, Toshio

AU - Miyakoshi, Kei

AU - Minegishi, Kazuhiro

AU - Tsuda, Hiroshi

AU - Iwata, Takashi

AU - Tanaka, Kyoko

AU - Fukuchi, Takeshi

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