TY - JOUR
T1 - Responses of brown adipose tissue activity to unloading in rats
AU - Yamashita, H.
AU - Ohira, Y.
AU - Wakatsuki, T.
AU - Yamamoto, M.
AU - Kizaki, T.
AU - Oh-Ishi, S.
AU - Sato, Y.
AU - Ohno, H.
PY - 1995
Y1 - 1995
N2 - To study the responses of thermogenic activity in brown adipose tissue (BAT) to unloading, male Wistar rats were hindlimb suspended for 10 days. Compared with control rats, a significant increase in the BAT-to-body mass ratio and considerable differences in chemical components in BAT were observed in the hindlimb-suspended rats. These findings indicate a marked increase in the thermogenic capacity in BAT of the experimental group. Likewise, the thermogenic activity (which was assessed by guanosine 5'- diphosphate binding to BAT mitochondria) was markedly greater in the mitochondria recovered from BAT of the hindlimb-suspended rats than in those from the control rats (1,610 ± 450 vs. 202 ± 132 pmol recovered). Moreover, the uncoupling protein content in the BAT mitochondrial fraction of the hindlimb-suspended rats was significantly higher (1.6-fold) than that in the control rats. As was expected, the uncoupling protein mRNA expression was greater in hindlimb-suspended rats than in control animals. These results suggest that chronic hindlimb suspension leads to an increase in both the thermogenic capacity and the activity in BAT of rats.
AB - To study the responses of thermogenic activity in brown adipose tissue (BAT) to unloading, male Wistar rats were hindlimb suspended for 10 days. Compared with control rats, a significant increase in the BAT-to-body mass ratio and considerable differences in chemical components in BAT were observed in the hindlimb-suspended rats. These findings indicate a marked increase in the thermogenic capacity in BAT of the experimental group. Likewise, the thermogenic activity (which was assessed by guanosine 5'- diphosphate binding to BAT mitochondria) was markedly greater in the mitochondria recovered from BAT of the hindlimb-suspended rats than in those from the control rats (1,610 ± 450 vs. 202 ± 132 pmol recovered). Moreover, the uncoupling protein content in the BAT mitochondrial fraction of the hindlimb-suspended rats was significantly higher (1.6-fold) than that in the control rats. As was expected, the uncoupling protein mRNA expression was greater in hindlimb-suspended rats than in control animals. These results suggest that chronic hindlimb suspension leads to an increase in both the thermogenic capacity and the activity in BAT of rats.
UR - https://www.scopus.com/pages/publications/0028872610
UR - https://www.scopus.com/pages/publications/0028872610#tab=citedBy
U2 - 10.1152/jappl.1995.78.2.384
DO - 10.1152/jappl.1995.78.2.384
M3 - Article
C2 - 7538994
AN - SCOPUS:0028872610
SN - 8750-7587
VL - 78
SP - 384
EP - 387
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 2
ER -