TY - JOUR
T1 - Restriction-modification systems may be associated with Helicobacter pylori virulence
AU - Ando, Takafumi
AU - Ishiguro, Kazuhiro
AU - Watanabe, Osamu
AU - Miyake, Nobuyuki
AU - Kato, Tsuyoshi
AU - Hibi, Satoshi
AU - Mimura, Shunya
AU - Nakamura, Masanao
AU - Miyahara, Ryoji
AU - Ohmiya, Naoki
AU - Niwa, Yasumasa
AU - Goto, Hidemi
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2010/5
Y1 - 2010/5
N2 - Restriction-modification (R-M) systems are exclusive to unicellular organisms and ubiquitous in the bacterial world. Bacteria use R-M systems as a defense against invasion by foreign DNA. Analysis of the genome sequences of Helicobacter pylori strains 26 695 and J99 identified an extraordinary number of genes with homology to R-M genes in other bacterial species. All H. pylori strains possess their own unique complement of active R-M systems. All of the methylases that have been studied so far were present in all major human population groupings, suggesting that their horizontal acquisition pre-dated the separation of these populations. The two most strongly conserved methylase genes of H. pylori, hpy IM and hpy IIIM, are both preceded by alternative genes that compete for presence at their loci, and furthermore these genes may be associated with H. pylori pathogenicity. Further study should investigate the roles of H. pylori R-M systems.
AB - Restriction-modification (R-M) systems are exclusive to unicellular organisms and ubiquitous in the bacterial world. Bacteria use R-M systems as a defense against invasion by foreign DNA. Analysis of the genome sequences of Helicobacter pylori strains 26 695 and J99 identified an extraordinary number of genes with homology to R-M genes in other bacterial species. All H. pylori strains possess their own unique complement of active R-M systems. All of the methylases that have been studied so far were present in all major human population groupings, suggesting that their horizontal acquisition pre-dated the separation of these populations. The two most strongly conserved methylase genes of H. pylori, hpy IM and hpy IIIM, are both preceded by alternative genes that compete for presence at their loci, and furthermore these genes may be associated with H. pylori pathogenicity. Further study should investigate the roles of H. pylori R-M systems.
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U2 - 10.1111/j.1440-1746.2009.06211.x
DO - 10.1111/j.1440-1746.2009.06211.x
M3 - Article
C2 - 20586875
AN - SCOPUS:77951556141
SN - 0815-9319
VL - 25
SP - S95-S98
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
IS - SUPPL. 1
ER -