TY - JOUR
T1 - RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations
AU - Iwakoshi, Akari
AU - Murakumo, Yoshiki
AU - Kato, Takuya
AU - Kitamura, Aya
AU - Mii, Shinji
AU - Saito, Shoji
AU - Yatabe, Yasushi
AU - Takahashi, Masahide
PY - 2012/5
Y1 - 2012/5
N2 - The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP is expressed in a variety of human and rodent tumor cell lines and in several kinds of human cancer. Expression of RFP is associated with prognosis of colon and endometrial cancers. In the present study, we evaluated the expression of RFP in lung cancer and assessed its clinical significance. Tissue microarrays were constructed from 108 cases of lung cancer, and the sections were analyzed for RFP expression by immunohistochemistry. RFP expression was detected in the nucleus in 66.7% of lung cancer tissues examined. RFP expression was statistically significantly associated with thyroid transcription factor 1 (TTF-1) expression (P= 0.028). However, no significant association was observed between RFP expression and other clinicopathological or genetic factors, including epidermal growth factor receptor (EGFR) mutations. Interestingly, we found that RFP expression correlated with poor prognosis in patients with EGFR mutations (P= 0.032). Our results suggest that RFP has a role in mutated EGFR signaling and that RFP status may be a prognostic factor for lung cancer with EGFR mutations.
AB - The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP is expressed in a variety of human and rodent tumor cell lines and in several kinds of human cancer. Expression of RFP is associated with prognosis of colon and endometrial cancers. In the present study, we evaluated the expression of RFP in lung cancer and assessed its clinical significance. Tissue microarrays were constructed from 108 cases of lung cancer, and the sections were analyzed for RFP expression by immunohistochemistry. RFP expression was detected in the nucleus in 66.7% of lung cancer tissues examined. RFP expression was statistically significantly associated with thyroid transcription factor 1 (TTF-1) expression (P= 0.028). However, no significant association was observed between RFP expression and other clinicopathological or genetic factors, including epidermal growth factor receptor (EGFR) mutations. Interestingly, we found that RFP expression correlated with poor prognosis in patients with EGFR mutations (P= 0.032). Our results suggest that RFP has a role in mutated EGFR signaling and that RFP status may be a prognostic factor for lung cancer with EGFR mutations.
UR - http://www.scopus.com/inward/record.url?scp=84860265022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860265022&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1827.2012.02797.x
DO - 10.1111/j.1440-1827.2012.02797.x
M3 - Article
C2 - 22524660
AN - SCOPUS:84860265022
SN - 1320-5463
VL - 62
SP - 324
EP - 330
JO - Pathology International
JF - Pathology International
IS - 5
ER -