RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis

Masashi Kato, Kozue Takeda, Yoshiyuki Kawamoto, Toyonori Tsuzuki, Yan Dai, Seiko Nakayama, Kazuhiro Toriyama, Yasuhiko Tamada, Masahide Takahashi, Izumi Nakashima

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


We first demonstrated that c-Ret protein is transiently expressed mainly in the inner and outer root sheaths of hair follicles soon after birth in the skin of normal C57BL/6 and BALB/c mice. A longer-lasting expression of activated RET protein overlapped the c-Ret expression with some preferential expression in the outer root sheath in close association with increase in the number of S-100 protein-containing cells in the area and excess melanogenesis in and around hair bulbs in the skin of RFP-RET-transgenic mice on a C57BL/6 background (RFP-RET/B6). Hair follicles in the skin of the transgenic mice continuously showed histology of the anagen phase, and the recovery period for the hair of the transgenic mice after shaving was shortened. Such growth promotion was not observed in the case of white hairs of RFP-RET-transgenic mice on a BALB/c background. These results suggest that RET works to extend the anagen phase in association with upregulation of melanin production.

Original languageEnglish
Pages (from-to)7536-7541
Number of pages6
Issue number51
Publication statusPublished - 08-11-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research


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