TY - JOUR
T1 - Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53
AU - Shadat, Noman Mohammod Abu
AU - Koide, Naoki
AU - Khuda, Imtiaz I.E.
AU - Dagvadorj, Jargalsaikhan
AU - Tumurkhuu, Gantsetseg
AU - Naiki, Yoshikazu
AU - Komatsu, Takayuki
AU - Yoshida, Tomoaki
AU - Yokochi, Takashi
N1 - Funding Information:
This work was supported by in part by a grant-in-aid for scientific research from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2010/9
Y1 - 2010/9
N2 - The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) on the cell growth of mouse and human monocytic leukemia cells was examined. RIZ1 expression was induced in response to tumor necrosis factor (TNF)-α. The expression was dependent on the nuclear factor-κB and AKT signaling. Further, RIZ1 expression led to the augmentation of p53 expression and the silencing of RIZ1 prevented it. On the other hand, a p53 inhibitor enhanced the TNF-α-induced RIZ1 expression. Silencing of RIZ1 augmented the proliferative activity of TNF-α-treated cells. Therefore, it is suggested that RIZ1 negatively regulated the cell proliferation of monocytic leukemia cells via activation of p53.
AB - The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) on the cell growth of mouse and human monocytic leukemia cells was examined. RIZ1 expression was induced in response to tumor necrosis factor (TNF)-α. The expression was dependent on the nuclear factor-κB and AKT signaling. Further, RIZ1 expression led to the augmentation of p53 expression and the silencing of RIZ1 prevented it. On the other hand, a p53 inhibitor enhanced the TNF-α-induced RIZ1 expression. Silencing of RIZ1 augmented the proliferative activity of TNF-α-treated cells. Therefore, it is suggested that RIZ1 negatively regulated the cell proliferation of monocytic leukemia cells via activation of p53.
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U2 - 10.3109/07357907.2010.494323
DO - 10.3109/07357907.2010.494323
M3 - Article
C2 - 20594067
AN - SCOPUS:77956642980
SN - 0735-7907
VL - 28
SP - 806
EP - 812
JO - Cancer Investigation
JF - Cancer Investigation
IS - 8
ER -
