Retrospective analysis of parkinsonian patients exhibiting normal 123I-MIBG cardiac uptake

Yasuaki Mizutani, Shinji Ito, Kenichiro Murate, Seiko Hirota, Takao Fukui, Chika Hikichi, Tomomasa Ishikawa, Sayuri Shima, Akihiro Ueda, Madoka Kizawa, Kunihiko Asakura, Tatsuro Mutoh

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Abstract

Background Although most patients with Parkinson's disease (PD) show decreased cardiac 123I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients. Methods We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 ± 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated > 30% reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N = 37) and other groups (N = 117). Results The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG H/M ratio in the delayed phase (delayed, p < 0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p < 0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods. Conclusions An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalJournal of the Neurological Sciences
Volume359
Issue number1-2
DOIs
Publication statusPublished - 15-12-2015

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Parkinson Disease
Mediastinum
Parkinsonian Disorders
Tremor
Radionuclide Imaging
Incidence

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Mizutani, Yasuaki ; Ito, Shinji ; Murate, Kenichiro ; Hirota, Seiko ; Fukui, Takao ; Hikichi, Chika ; Ishikawa, Tomomasa ; Shima, Sayuri ; Ueda, Akihiro ; Kizawa, Madoka ; Asakura, Kunihiko ; Mutoh, Tatsuro. / Retrospective analysis of parkinsonian patients exhibiting normal 123I-MIBG cardiac uptake. In: Journal of the Neurological Sciences. 2015 ; Vol. 359, No. 1-2. pp. 236-240.
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abstract = "Background Although most patients with Parkinson's disease (PD) show decreased cardiac 123I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients. Methods We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 ± 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated > 30{\%} reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N = 37) and other groups (N = 117). Results The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG H/M ratio in the delayed phase (delayed, p < 0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p < 0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods. Conclusions An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients.",
author = "Yasuaki Mizutani and Shinji Ito and Kenichiro Murate and Seiko Hirota and Takao Fukui and Chika Hikichi and Tomomasa Ishikawa and Sayuri Shima and Akihiro Ueda and Madoka Kizawa and Kunihiko Asakura and Tatsuro Mutoh",
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Mizutani, Y, Ito, S, Murate, K, Hirota, S, Fukui, T, Hikichi, C, Ishikawa, T, Shima, S, Ueda, A, Kizawa, M, Asakura, K & Mutoh, T 2015, 'Retrospective analysis of parkinsonian patients exhibiting normal 123I-MIBG cardiac uptake', Journal of the Neurological Sciences, vol. 359, no. 1-2, pp. 236-240. https://doi.org/10.1016/j.jns.2015.10.059

Retrospective analysis of parkinsonian patients exhibiting normal 123I-MIBG cardiac uptake. / Mizutani, Yasuaki; Ito, Shinji; Murate, Kenichiro; Hirota, Seiko; Fukui, Takao; Hikichi, Chika; Ishikawa, Tomomasa; Shima, Sayuri; Ueda, Akihiro; Kizawa, Madoka; Asakura, Kunihiko; Mutoh, Tatsuro.

In: Journal of the Neurological Sciences, Vol. 359, No. 1-2, 15.12.2015, p. 236-240.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Retrospective analysis of parkinsonian patients exhibiting normal 123I-MIBG cardiac uptake

AU - Mizutani, Yasuaki

AU - Ito, Shinji

AU - Murate, Kenichiro

AU - Hirota, Seiko

AU - Fukui, Takao

AU - Hikichi, Chika

AU - Ishikawa, Tomomasa

AU - Shima, Sayuri

AU - Ueda, Akihiro

AU - Kizawa, Madoka

AU - Asakura, Kunihiko

AU - Mutoh, Tatsuro

PY - 2015/12/15

Y1 - 2015/12/15

N2 - Background Although most patients with Parkinson's disease (PD) show decreased cardiac 123I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients. Methods We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 ± 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated > 30% reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N = 37) and other groups (N = 117). Results The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG H/M ratio in the delayed phase (delayed, p < 0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p < 0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods. Conclusions An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients.

AB - Background Although most patients with Parkinson's disease (PD) show decreased cardiac 123I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients. Methods We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 ± 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated > 30% reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N = 37) and other groups (N = 117). Results The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG H/M ratio in the delayed phase (delayed, p < 0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p < 0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods. Conclusions An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients.

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