Retrospective study of acute myelogenous leukemia in elderly patients: treatment and outcome of 83 consecutive patients

T. Ino, M. Tsuzuki, A. Hasegawa, H. Miyazaki, H. Kojima, F. Maruyama, M. Okamoto, T. Matsui, K. Ezaki, M. Hirano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We retrospectively analyzed treatments and outcomes for 83 acute myelogenous leukemia (AML) patients aged 60 years or more (median age 71) admitted to our hospital between August 1984 and January 1998. Complete remission was achieved in 36% of 78 patients who received anti-leukemic therapy, and median overall survival was 227 days. In addition to abnormal karyotypes involving chromosome 5 or 7, administration of less than 120 mg/m2/course of daunorubicin (DNR) during the initial treatment phase was an unfavorable prognostic factor for both CR and survival. Only 41% of all patients received 120 mg/m2/course of DNR or more, and had a significantly higher CR rate (56%) and longer survival, with a median of 389 days. It was suggested that intensive chemotherapy was effective for selected elderly AML patients who were relatively younger and had good performance status, although the number of such patients was limited in our study.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume41
Issue number4
Publication statusPublished - 04-2000

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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