Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513

Toshitaka Nabeshima, Keiko Tohyama, Tsutomu Kameyama

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We investigated the effects of benzodiazepine inverse agonists on ethanol-induced amnesia using a passive avoidance task. Pretraining treatment of mice with ethanol significantly impaired the passive avoidance response: there was a significant reduction in the % retention and step-down latency. The benzodiazepine inverse agonists, Ro 15-4513 and β-CCM, significantly increased the % retention and prolonged the step-down latencies in mice treated with ethanol, but FG 7142 did not. The anti-amnesic effect of Ro 15-4513 were completely antagonized by co-administration of Ro 15-1788, a benzodiazepine antagonist. These results suggest that the anti-amnesic effect of Ro 15-4513 on alcohol-induced amnesia is mediated by benzodiazepine receptors.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalEuropean Journal of Pharmacology
Volume155
Issue number3
DOIs
Publication statusPublished - 18-10-1988
Externally publishedYes

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Amnesia
Benzodiazepines
Ethanol
Alcohols
Flumazenil
GABA-A Receptors
Ro 15-4513

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

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abstract = "We investigated the effects of benzodiazepine inverse agonists on ethanol-induced amnesia using a passive avoidance task. Pretraining treatment of mice with ethanol significantly impaired the passive avoidance response: there was a significant reduction in the {\%} retention and step-down latency. The benzodiazepine inverse agonists, Ro 15-4513 and β-CCM, significantly increased the {\%} retention and prolonged the step-down latencies in mice treated with ethanol, but FG 7142 did not. The anti-amnesic effect of Ro 15-4513 were completely antagonized by co-administration of Ro 15-1788, a benzodiazepine antagonist. These results suggest that the anti-amnesic effect of Ro 15-4513 on alcohol-induced amnesia is mediated by benzodiazepine receptors.",
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Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513. / Nabeshima, Toshitaka; Tohyama, Keiko; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 155, No. 3, 18.10.1988, p. 211-217.

Research output: Contribution to journalArticle

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