TY - JOUR
T1 - Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513
AU - Nabeshima, Toshitaka
AU - Tohyama, Keiko
AU - Kameyama, Tsutomu
PY - 1988/10/18
Y1 - 1988/10/18
N2 - We investigated the effects of benzodiazepine inverse agonists on ethanol-induced amnesia using a passive avoidance task. Pretraining treatment of mice with ethanol significantly impaired the passive avoidance response: there was a significant reduction in the % retention and step-down latency. The benzodiazepine inverse agonists, Ro 15-4513 and β-CCM, significantly increased the % retention and prolonged the step-down latencies in mice treated with ethanol, but FG 7142 did not. The anti-amnesic effect of Ro 15-4513 were completely antagonized by co-administration of Ro 15-1788, a benzodiazepine antagonist. These results suggest that the anti-amnesic effect of Ro 15-4513 on alcohol-induced amnesia is mediated by benzodiazepine receptors.
AB - We investigated the effects of benzodiazepine inverse agonists on ethanol-induced amnesia using a passive avoidance task. Pretraining treatment of mice with ethanol significantly impaired the passive avoidance response: there was a significant reduction in the % retention and step-down latency. The benzodiazepine inverse agonists, Ro 15-4513 and β-CCM, significantly increased the % retention and prolonged the step-down latencies in mice treated with ethanol, but FG 7142 did not. The anti-amnesic effect of Ro 15-4513 were completely antagonized by co-administration of Ro 15-1788, a benzodiazepine antagonist. These results suggest that the anti-amnesic effect of Ro 15-4513 on alcohol-induced amnesia is mediated by benzodiazepine receptors.
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U2 - 10.1016/0014-2999(88)90506-7
DO - 10.1016/0014-2999(88)90506-7
M3 - Article
C2 - 3148475
AN - SCOPUS:0023723268
SN - 0014-2999
VL - 155
SP - 211
EP - 217
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -