Reverse genetics system for human rotaviruses

Satoshi Komoto, Saori Fukuda, Takayuki Murata, Koki Taniguchi

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


A reverse genetics technology is an incredibly useful technique both for a proper understanding of different aspects of virus biology and for the generation of complementary DNA (cDNA)-derived infectious viruses, which can act as safe and effective vaccines and viral vectors. Rotaviruses (RVAs), especially human RVAs (HuRVAs), had been very refractory to this technology until very recently. Here, we describe the historical background of the development of a long-awaited HuRVA reverse genetics system, culminating in the generation of replicative HuRVAs entirely from cloned cDNAs.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
Issue number6
Publication statusPublished - 01-06-2020

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology


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