Reversible conduction failure in anti-lactosylceramide-antibody-positive combined central and peripheral demyelination

Masaya Harada; Shiroh Miura; Hiroshi Kida; Taiga Moritaka; Ken Ichi Irie; Takashi Kamada; Yusuke Uchiyama; Sayuri Shima; Tatsuro Mutoh; Tomoaki Hoshino; Takayuki Taniwaki

doi:10.3389/fneur.2019.00600

Reversible conduction failure in anti-lactosylceramide-antibody-positive combined central and peripheral demyelination

Masaya Harada, Shiroh Miura, Hiroshi Kida, Taiga Moritaka, Ken Ichi Irie, Takashi Kamada, Yusuke Uchiyama, Sayuri Shima, Tatsuro Mutoh, Tomoaki Hoshino, Takayuki Taniwaki

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3 Citations (Scopus)

Abstract

We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.

Original language	English
Article number	600
Journal	Frontiers in Neurology
Volume	10
Issue number	JUN
DOIs	https://doi.org/10.3389/fneur.2019.00600
Publication status	Published - 2019

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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title = "Reversible conduction failure in anti-lactosylceramide-antibody-positive combined central and peripheral demyelination",

abstract = "We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.",

author = "Masaya Harada and Shiroh Miura and Hiroshi Kida and Taiga Moritaka and Irie, {Ken Ichi} and Takashi Kamada and Yusuke Uchiyama and Sayuri Shima and Tatsuro Mutoh and Tomoaki Hoshino and Takayuki Taniwaki",

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doi = "10.3389/fneur.2019.00600",

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T1 - Reversible conduction failure in anti-lactosylceramide-antibody-positive combined central and peripheral demyelination

AU - Harada, Masaya

AU - Miura, Shiroh

AU - Kida, Hiroshi

AU - Moritaka, Taiga

AU - Irie, Ken Ichi

AU - Kamada, Takashi

AU - Uchiyama, Yusuke

AU - Shima, Sayuri

AU - Mutoh, Tatsuro

AU - Hoshino, Tomoaki

AU - Taniwaki, Takayuki

PY - 2019

Y1 - 2019

N2 - We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.

AB - We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.

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Reversible conduction failure in anti-lactosylceramide-antibody-positive combined central and peripheral demyelination

Abstract

All Science Journal Classification (ASJC) codes

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