Reversible conduction failure in anti-lactosylceramide-antibody-positive combined central and peripheral demyelination

Masaya Harada, Shiroh Miura, Hiroshi Kida, Taiga Moritaka, Ken Ichi Irie, Takashi Kamada, Yusuke Uchiyama, Sayuri Shima, Tatsuro Mutoh, Tomoaki Hoshino, Takayuki Taniwaki

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.

Original languageEnglish
Article number600
JournalFrontiers in Neurology
Volume10
Issue numberJUN
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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