Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients

Masatoshi Ishigami, Takashi Honda, Teiji Kuzuya, Yoji Ishizu, Takanori Ito, Hideya Kamei, Yasuhiro Ogura, Mitsuhiro Fujishiro

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: In this study, we investigated long-term survival of cirrhotic patients without hepatocellular carcinoma (HCC) and the proper timing of liver transplantation in the era with recent progress of management. Methods: We first classified 217 non-transplant cirrhotic patients without HCC according to the long-term survival based on Child-Turcotte-Pugh (CTP) scores and the MELD scores. We then compared them with the survival after liver transplantation in 114 patients with liver cirrhosis. Results: We classified into four groups (class A as CTP score of 5,6, B as 7,8, C as 9-12, D as 13-15) according to the long-term survival of the patients, the survivals of patients with class C and D were significantly worse compared with transplant patients (P < 0.001 in each group). And we also classified into four groups based on the MELD scores (class A as MELD score of −8, B as 9-12, C as 13-19, D as 19-), the survivals of patients with class C and D were significantly worse compared with those of transplant patients (P < 0.001 in each group). Conclusions: Considering the long-term survival of patients with liver cirrhosis, CTP score of 9 and/or MELD score of 13 could be a proper timing for liver transplantation.

Original languageEnglish
Pages (from-to)655-662
Number of pages8
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume27
Issue number9
DOIs
Publication statusPublished - 01-09-2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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