Rheumatoid arthritis and B cell lymphoma with pathological changes of reactive histiocytosis

M. Shimada, M. Kojima, G. Tani, S. Komatsumoto, M. Nara

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2 Citations (Scopus)


A 67 year old woman with rheumatoid arthritis was admitted to hospital in acute renal failure. Her clinical features included increasing dyspnoea and oedema, and a computed tomogram of the abdomen showed a large mass in the retroperitoneum. Twenty six days later, she died, and a post mortem examination was carried out. The histological changes of the mass indicated B cell lymphoma of diffuse large cell type, with a reactive proliferation of erythrophagocytosing histiocytes. Immunocytochemical studies showed that the histiocytes were positive for CD-68 and lysozyme, but negative for S-100 protein. Such neoplastic B cell proliferation accompanied by activation of benign looking histiocytes with erythrophagocytosis is very rare.

Original languageEnglish
Pages (from-to)1064
Number of pages1
JournalJournal of Clinical Pathology
Issue number11
Publication statusPublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


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