TY - JOUR
T1 - Rhinorrhea in Parkinson's disease
T2 - A consecutive multicenter study in Japan
AU - Kano, Osamu
AU - Yoshioka, Masayuki
AU - Nagayama, Hiroshi
AU - Hamada, Shinsuke
AU - Maeda, Tetsuya
AU - Hasegawa, Takafumi
AU - Kadowaki, Taro
AU - Sengoku, Renpei
AU - Terashi, Hiroo
AU - Hatano, Taku
AU - Nomoto, Nobuatsu
AU - Inoue, Manabu
AU - Shimura, Hideki
AU - Takahashi, Tatsuya
AU - Uchiyama, Tsuyoshi
AU - Watanabe, Hirohisa
AU - Kaneko, Satoshi
AU - Takahashi, Tetsuya
AU - Baba, Yasuhiko
AU - Kubo, Shin Ichiro
PY - 2014/8/15
Y1 - 2014/8/15
N2 - Recent reports suggest that rhinorrhea, defined as the presence of a runny nose unrelated to respiratory infections, allergies, or sinus problems, occurs more frequently among patients with Parkinson's disease (PD) than among healthy controls. We conducted a questionnaire survey in a multicenter study throughout Japan and compared the frequency of rhinorrhea between 231 PD and 187 normal control (NC) subjects. After excluding patients with rhinitis or paranasal sinusitis, a total of 159 PD and 59 NC subjects were included in our analysis. Rhinorrhea occurred more frequently in PD patients than NC subjects (33.3% vs. 11.9%; P = 0.01). Among PD patients, rhinorrhea was more common in men than women (P = 0.005). Rhinorrhea was not correlated with disease duration, modified Hoehn and Yahr score, disease type (akinesia rigidity vs. tremor dominant), or cardiac sympathetic function (evaluated by 123I- metaiodobenzylguanidine uptake). To our knowledge, this is the first multicenter study on the frequency of PD-related rhinorrhea in Asian countries.
AB - Recent reports suggest that rhinorrhea, defined as the presence of a runny nose unrelated to respiratory infections, allergies, or sinus problems, occurs more frequently among patients with Parkinson's disease (PD) than among healthy controls. We conducted a questionnaire survey in a multicenter study throughout Japan and compared the frequency of rhinorrhea between 231 PD and 187 normal control (NC) subjects. After excluding patients with rhinitis or paranasal sinusitis, a total of 159 PD and 59 NC subjects were included in our analysis. Rhinorrhea occurred more frequently in PD patients than NC subjects (33.3% vs. 11.9%; P = 0.01). Among PD patients, rhinorrhea was more common in men than women (P = 0.005). Rhinorrhea was not correlated with disease duration, modified Hoehn and Yahr score, disease type (akinesia rigidity vs. tremor dominant), or cardiac sympathetic function (evaluated by 123I- metaiodobenzylguanidine uptake). To our knowledge, this is the first multicenter study on the frequency of PD-related rhinorrhea in Asian countries.
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U2 - 10.1016/j.jns.2014.05.039
DO - 10.1016/j.jns.2014.05.039
M3 - Article
C2 - 24932941
AN - SCOPUS:84904257791
SN - 0022-510X
VL - 343
SP - 88
EP - 90
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -