Rho-family GTPases in cadherin-mediated cell-cell adhesion

Masaki Fukata, Kozo Kaibuchi

Research output: Contribution to journalReview articlepeer-review

361 Citations (Scopus)


Cell-cell adhesions are rearranged dynamically during tissue development and tumour metastasis. Recently, Rho-family GTPases, including RhoA, Rac1 and Cdc42, have emerged as key regulators of cadherin-mediated cell-cell adhesion. Following the identification and characterization of regulators and effectors of Rho GTPases, signal transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to cadherin, are beginning to be clarified.

Original languageEnglish
Pages (from-to)887-897
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number12
Publication statusPublished - 12-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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