Les protéines Rho: Leur rôle dans les neurones

Translated title of the contribution: Rho GTpases function in neurons

Céline Ménager, Kozo Kaibuchi

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Neurons possess a polarized morphology. In general, each neuron has several dendrites but only one axon. Such morphology is the basis for directionalized rapid signaling, information flowing from the short dendrites to the long axon. The mechanisms involved in the establishment of the neuronal polarity remain largely unknown. However, recently, members of Rho family proteins have been implicated in the regulation of neuronal morphology especially development of neuronal polarity, axon outgrowth and guidance, dendritic tree elaboration and synapse formation. Moreover, the Rho GTPases have been reported to be directly or indirectly involved in some neurological conditions such as X-linked mental retardation as well as Alzheimer's and Parkinson's diseases. These findings demonstrate the importance of Rho GTPases in the development, maintenance and function of the nervous system.

Translated title of the contributionRho GTpases function in neurons
Original languageFrench
Pages (from-to)358-363
Number of pages6
JournalMedecine/Sciences
Volume19
Issue number3
Publication statusPublished - 01-03-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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