Abstract
10.1002/cm.20472.absRho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase.
| Original language | English |
|---|---|
| Pages (from-to) | 545-554 |
| Number of pages | 10 |
| Journal | Cytoskeleton |
| Volume | 67 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 09-2010 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Structural Biology
- Cell Biology