Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women: A large population-based, prospective cohort study

Ehab S. Eshak, Hiroyasu Iso, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Manami Inoue, Shoichiro Tsugane

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Abstract

Background: Rice consumption has been associated with risk of type 2 diabetes, but its relation with cardiovascular disease (CVD) is limited. Objective: We examined the association between rice consumption and risk of CVD incidence and mortality in a Japanese population. Design: This was a prospective study in 91,223 Japanese men and women aged 40-69 y in whom rice consumption was determined and updated from 3 self-administered food-frequency questionnaires, each 5 y apart. Follow-up for incidence was from 1990 to 2009 in cohort I and 1993 to 2007 in cohort II and for mortality was from 1990 to 2009 in cohort I and 1993 to 2009 in cohort II. HRs and 95% CIs of CVD incidence and mortality were calculated according to quintiles of cumulative average rice consumption. Results: In 15-18 y of follow-up, we ascertained 4395 incident cases of stroke, 1088 incident cases of ischemic heart disease (IHD), and 2705 deaths from CVD. Rice consumption was not associated with risk of incident stroke or IHD; the multivariable HR (95% CI) in the highest compared with lowest rice consumption quintiles was 1.01 (0.90, 1.14) for total stroke and 1.08 (0.84, 1.38) for IHD. Similarly, there was no association between rice consumption and risk of mortality from CVD; the HR (95% CI) for mortality from total CVD was 0.97 (0.84, 1.13). There were no interactions with sex or effect modifications by body mass index for any endpoint. Conclusion: Rice consumption is not associated with risk of CVD morbidity or mortality.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume100
Issue number1
DOIs
Publication statusPublished - 01-07-2014

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Cohort Studies
Cardiovascular Diseases
Prospective Studies
Morbidity
Mortality
Population
Myocardial Ischemia
Stroke
Incidence
Oryza
Type 2 Diabetes Mellitus
Body Mass Index
Food

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Eshak, Ehab S. ; Iso, Hiroyasu ; Yamagishi, Kazumasa ; Kokubo, Yoshihiro ; Saito, Isao ; Yatsuya, Hiroshi ; Sawada, Norie ; Inoue, Manami ; Tsugane, Shoichiro. / Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women : A large population-based, prospective cohort study. In: American Journal of Clinical Nutrition. 2014 ; Vol. 100, No. 1. pp. 199-207.
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abstract = "Background: Rice consumption has been associated with risk of type 2 diabetes, but its relation with cardiovascular disease (CVD) is limited. Objective: We examined the association between rice consumption and risk of CVD incidence and mortality in a Japanese population. Design: This was a prospective study in 91,223 Japanese men and women aged 40-69 y in whom rice consumption was determined and updated from 3 self-administered food-frequency questionnaires, each 5 y apart. Follow-up for incidence was from 1990 to 2009 in cohort I and 1993 to 2007 in cohort II and for mortality was from 1990 to 2009 in cohort I and 1993 to 2009 in cohort II. HRs and 95{\%} CIs of CVD incidence and mortality were calculated according to quintiles of cumulative average rice consumption. Results: In 15-18 y of follow-up, we ascertained 4395 incident cases of stroke, 1088 incident cases of ischemic heart disease (IHD), and 2705 deaths from CVD. Rice consumption was not associated with risk of incident stroke or IHD; the multivariable HR (95{\%} CI) in the highest compared with lowest rice consumption quintiles was 1.01 (0.90, 1.14) for total stroke and 1.08 (0.84, 1.38) for IHD. Similarly, there was no association between rice consumption and risk of mortality from CVD; the HR (95{\%} CI) for mortality from total CVD was 0.97 (0.84, 1.13). There were no interactions with sex or effect modifications by body mass index for any endpoint. Conclusion: Rice consumption is not associated with risk of CVD morbidity or mortality.",
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Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women : A large population-based, prospective cohort study. / Eshak, Ehab S.; Iso, Hiroyasu; Yamagishi, Kazumasa; Kokubo, Yoshihiro; Saito, Isao; Yatsuya, Hiroshi; Sawada, Norie; Inoue, Manami; Tsugane, Shoichiro.

In: American Journal of Clinical Nutrition, Vol. 100, No. 1, 01.07.2014, p. 199-207.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women

T2 - A large population-based, prospective cohort study

AU - Eshak, Ehab S.

AU - Iso, Hiroyasu

AU - Yamagishi, Kazumasa

AU - Kokubo, Yoshihiro

AU - Saito, Isao

AU - Yatsuya, Hiroshi

AU - Sawada, Norie

AU - Inoue, Manami

AU - Tsugane, Shoichiro

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Background: Rice consumption has been associated with risk of type 2 diabetes, but its relation with cardiovascular disease (CVD) is limited. Objective: We examined the association between rice consumption and risk of CVD incidence and mortality in a Japanese population. Design: This was a prospective study in 91,223 Japanese men and women aged 40-69 y in whom rice consumption was determined and updated from 3 self-administered food-frequency questionnaires, each 5 y apart. Follow-up for incidence was from 1990 to 2009 in cohort I and 1993 to 2007 in cohort II and for mortality was from 1990 to 2009 in cohort I and 1993 to 2009 in cohort II. HRs and 95% CIs of CVD incidence and mortality were calculated according to quintiles of cumulative average rice consumption. Results: In 15-18 y of follow-up, we ascertained 4395 incident cases of stroke, 1088 incident cases of ischemic heart disease (IHD), and 2705 deaths from CVD. Rice consumption was not associated with risk of incident stroke or IHD; the multivariable HR (95% CI) in the highest compared with lowest rice consumption quintiles was 1.01 (0.90, 1.14) for total stroke and 1.08 (0.84, 1.38) for IHD. Similarly, there was no association between rice consumption and risk of mortality from CVD; the HR (95% CI) for mortality from total CVD was 0.97 (0.84, 1.13). There were no interactions with sex or effect modifications by body mass index for any endpoint. Conclusion: Rice consumption is not associated with risk of CVD morbidity or mortality.

AB - Background: Rice consumption has been associated with risk of type 2 diabetes, but its relation with cardiovascular disease (CVD) is limited. Objective: We examined the association between rice consumption and risk of CVD incidence and mortality in a Japanese population. Design: This was a prospective study in 91,223 Japanese men and women aged 40-69 y in whom rice consumption was determined and updated from 3 self-administered food-frequency questionnaires, each 5 y apart. Follow-up for incidence was from 1990 to 2009 in cohort I and 1993 to 2007 in cohort II and for mortality was from 1990 to 2009 in cohort I and 1993 to 2009 in cohort II. HRs and 95% CIs of CVD incidence and mortality were calculated according to quintiles of cumulative average rice consumption. Results: In 15-18 y of follow-up, we ascertained 4395 incident cases of stroke, 1088 incident cases of ischemic heart disease (IHD), and 2705 deaths from CVD. Rice consumption was not associated with risk of incident stroke or IHD; the multivariable HR (95% CI) in the highest compared with lowest rice consumption quintiles was 1.01 (0.90, 1.14) for total stroke and 1.08 (0.84, 1.38) for IHD. Similarly, there was no association between rice consumption and risk of mortality from CVD; the HR (95% CI) for mortality from total CVD was 0.97 (0.84, 1.13). There were no interactions with sex or effect modifications by body mass index for any endpoint. Conclusion: Rice consumption is not associated with risk of CVD morbidity or mortality.

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