Right-hemispheric dominance of spatial memory in split-brain mice

Yoshiaki Shinohara, Aki Hosoya, Nobuyuki Yamasaki, Hassan Ahmed, Satoko Takai, Megumi Eguchi, Shun Yamaguchi, Tsuyoshi Miyakawa, Hajime Hirase, Ryuichi Shigemoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of "split-brain" mice in the Barnes maze. The "split-brain" mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalHippocampus
Volume22
Issue number2
DOIs
Publication statusPublished - 01-02-2012

Fingerprint

Split-Brain Procedure
Hippocampus
Brain Fornix
Sensory Deprivation
Corpus Callosum
Brain
Task Performance and Analysis
Spatial Memory
Synapses
Fear

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Cite this

Shinohara, Y., Hosoya, A., Yamasaki, N., Ahmed, H., Takai, S., Eguchi, M., ... Shigemoto, R. (2012). Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus, 22(2), 117-121. https://doi.org/10.1002/hipo.20886
Shinohara, Yoshiaki ; Hosoya, Aki ; Yamasaki, Nobuyuki ; Ahmed, Hassan ; Takai, Satoko ; Eguchi, Megumi ; Yamaguchi, Shun ; Miyakawa, Tsuyoshi ; Hirase, Hajime ; Shigemoto, Ryuichi. / Right-hemispheric dominance of spatial memory in split-brain mice. In: Hippocampus. 2012 ; Vol. 22, No. 2. pp. 117-121.
@article{635179d2de454b94ae3a459552ab7b21,
title = "Right-hemispheric dominance of spatial memory in split-brain mice",
abstract = "Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of {"}split-brain{"} mice in the Barnes maze. The {"}split-brain{"} mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus.",
author = "Yoshiaki Shinohara and Aki Hosoya and Nobuyuki Yamasaki and Hassan Ahmed and Satoko Takai and Megumi Eguchi and Shun Yamaguchi and Tsuyoshi Miyakawa and Hajime Hirase and Ryuichi Shigemoto",
year = "2012",
month = "2",
day = "1",
doi = "10.1002/hipo.20886",
language = "English",
volume = "22",
pages = "117--121",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",
number = "2",

}

Shinohara, Y, Hosoya, A, Yamasaki, N, Ahmed, H, Takai, S, Eguchi, M, Yamaguchi, S, Miyakawa, T, Hirase, H & Shigemoto, R 2012, 'Right-hemispheric dominance of spatial memory in split-brain mice', Hippocampus, vol. 22, no. 2, pp. 117-121. https://doi.org/10.1002/hipo.20886

Right-hemispheric dominance of spatial memory in split-brain mice. / Shinohara, Yoshiaki; Hosoya, Aki; Yamasaki, Nobuyuki; Ahmed, Hassan; Takai, Satoko; Eguchi, Megumi; Yamaguchi, Shun; Miyakawa, Tsuyoshi; Hirase, Hajime; Shigemoto, Ryuichi.

In: Hippocampus, Vol. 22, No. 2, 01.02.2012, p. 117-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Right-hemispheric dominance of spatial memory in split-brain mice

AU - Shinohara, Yoshiaki

AU - Hosoya, Aki

AU - Yamasaki, Nobuyuki

AU - Ahmed, Hassan

AU - Takai, Satoko

AU - Eguchi, Megumi

AU - Yamaguchi, Shun

AU - Miyakawa, Tsuyoshi

AU - Hirase, Hajime

AU - Shigemoto, Ryuichi

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of "split-brain" mice in the Barnes maze. The "split-brain" mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus.

AB - Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of "split-brain" mice in the Barnes maze. The "split-brain" mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus.

UR - http://www.scopus.com/inward/record.url?scp=84856102621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856102621&partnerID=8YFLogxK

U2 - 10.1002/hipo.20886

DO - 10.1002/hipo.20886

M3 - Article

C2 - 21069782

AN - SCOPUS:84856102621

VL - 22

SP - 117

EP - 121

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

IS - 2

ER -

Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Takai S, Eguchi M et al. Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus. 2012 Feb 1;22(2):117-121. https://doi.org/10.1002/hipo.20886