Ripply2 is essential for precise somite formation during mouse early development

Techuan Chan, Akiko Kondow, Akihiro Hosoya, Keisuke Hitachi, Akira Yukita, Koji Okabayashi, Hiroaki Nakamura, Hidehiro Ozawa, Hiroshi Kiyonari, Tatsuo Michiue, Yuzuru Ito, Makoto Asashima

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Abstract

The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity.

Original languageEnglish
Pages (from-to)2691-2696
Number of pages6
JournalFEBS Letters
Volume581
Issue number14
DOIs
Publication statusPublished - 12-06-2007

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Chan, T., Kondow, A., Hosoya, A., Hitachi, K., Yukita, A., Okabayashi, K., Nakamura, H., Ozawa, H., Kiyonari, H., Michiue, T., Ito, Y., & Asashima, M. (2007). Ripply2 is essential for precise somite formation during mouse early development. FEBS Letters, 581(14), 2691-2696. https://doi.org/10.1016/j.febslet.2007.05.017