Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

Yuriko Fukuta, Robert R. Muder, Mounzer E. Agha, Lloyd G. Clarke, Marilyn M. Wagener, Amelia M. Hensler, Yohei Doi

Research output: Contribution to journalArticle

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Abstract

Background Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited. Methods We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii. Results A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P =.036), need for dialysis (P =.01), admission for other reasons except elective surgery (P =.03), transfer from other health care facilities (P =.02), prolonged intensive care unit stay (P =.004), mechanical ventilation (P <.001), pressor use (P =.001), tube feeding (P <.001), transfusion (P =.009), and prior antimicrobial use (P <.001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P =.04) and prolonged intensive care unit stay (OR, 19.28; P =.01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P =.001). The 90-day mortality rates were 41.9% and 29.0%, respectively (P =.20). Conclusions Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.

Original languageEnglish
Pages (from-to)1249-1252
Number of pages4
JournalAmerican Journal of Infection Control
Volume41
Issue number12
DOIs
Publication statusPublished - 01-12-2013
Externally publishedYes

Fingerprint

Acinetobacter baumannii
Neoplasms
Intensive Care Units
Inpatients
Dialysis
Acinetobacter Infections
Odds Ratio
Health Facilities
Enteral Nutrition
Hematologic Neoplasms
Cross Infection
Artificial Respiration
General Hospitals
Case-Control Studies
Length of Stay
Multivariate Analysis
Delivery of Health Care
Mortality

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Fukuta, Yuriko ; Muder, Robert R. ; Agha, Mounzer E. ; Clarke, Lloyd G. ; Wagener, Marilyn M. ; Hensler, Amelia M. ; Doi, Yohei. / Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients. In: American Journal of Infection Control. 2013 ; Vol. 41, No. 12. pp. 1249-1252.
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abstract = "Background Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited. Methods We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii. Results A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P =.036), need for dialysis (P =.01), admission for other reasons except elective surgery (P =.03), transfer from other health care facilities (P =.02), prolonged intensive care unit stay (P =.004), mechanical ventilation (P <.001), pressor use (P =.001), tube feeding (P <.001), transfusion (P =.009), and prior antimicrobial use (P <.001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P =.04) and prolonged intensive care unit stay (OR, 19.28; P =.01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P =.001). The 90-day mortality rates were 41.9{\%} and 29.0{\%}, respectively (P =.20). Conclusions Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.",
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Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients. / Fukuta, Yuriko; Muder, Robert R.; Agha, Mounzer E.; Clarke, Lloyd G.; Wagener, Marilyn M.; Hensler, Amelia M.; Doi, Yohei.

In: American Journal of Infection Control, Vol. 41, No. 12, 01.12.2013, p. 1249-1252.

Research output: Contribution to journalArticle

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T1 - Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

AU - Fukuta, Yuriko

AU - Muder, Robert R.

AU - Agha, Mounzer E.

AU - Clarke, Lloyd G.

AU - Wagener, Marilyn M.

AU - Hensler, Amelia M.

AU - Doi, Yohei

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N2 - Background Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited. Methods We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii. Results A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P =.036), need for dialysis (P =.01), admission for other reasons except elective surgery (P =.03), transfer from other health care facilities (P =.02), prolonged intensive care unit stay (P =.004), mechanical ventilation (P <.001), pressor use (P =.001), tube feeding (P <.001), transfusion (P =.009), and prior antimicrobial use (P <.001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P =.04) and prolonged intensive care unit stay (OR, 19.28; P =.01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P =.001). The 90-day mortality rates were 41.9% and 29.0%, respectively (P =.20). Conclusions Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.

AB - Background Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited. Methods We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii. Results A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P =.036), need for dialysis (P =.01), admission for other reasons except elective surgery (P =.03), transfer from other health care facilities (P =.02), prolonged intensive care unit stay (P =.004), mechanical ventilation (P <.001), pressor use (P =.001), tube feeding (P <.001), transfusion (P =.009), and prior antimicrobial use (P <.001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P =.04) and prolonged intensive care unit stay (OR, 19.28; P =.01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P =.001). The 90-day mortality rates were 41.9% and 29.0%, respectively (P =.20). Conclusions Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.

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