Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

Yuriko Fukuta, Robert R. Muder, Mounzer E. Agha, Lloyd G. Clarke, Marilyn M. Wagener, Amelia M. Hensler, Yohei Doi

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26 Citations (Scopus)

Abstract

Background Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited. Methods We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii. Results A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P =.036), need for dialysis (P =.01), admission for other reasons except elective surgery (P =.03), transfer from other health care facilities (P =.02), prolonged intensive care unit stay (P =.004), mechanical ventilation (P <.001), pressor use (P =.001), tube feeding (P <.001), transfusion (P =.009), and prior antimicrobial use (P <.001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P =.04) and prolonged intensive care unit stay (OR, 19.28; P =.01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P =.001). The 90-day mortality rates were 41.9% and 29.0%, respectively (P =.20). Conclusions Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.

Original languageEnglish
Pages (from-to)1249-1252
Number of pages4
JournalAmerican Journal of Infection Control
Volume41
Issue number12
DOIs
Publication statusPublished - 01-12-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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