TY - JOUR
T1 - Risk factors for coronary atherosclerosis in a general Japanese population
T2 - The Hisayama study
AU - Nakashima, Yutaka
AU - Kiyohara, Yutaka
AU - Doi, Yasufumi
AU - Kubo, Michiaki
AU - Iida, Mitsuo
AU - Sueishi, Katsuo
N1 - Funding Information:
The authors gratefully acknowledge Hiroshi Fujii for his expert technical assistance. This study was supported by Grants-in-Aid for Scientific Research A (No. 18209024) and C (No. 20591063) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.
PY - 2009/10/15
Y1 - 2009/10/15
N2 - To investigate risk factors for coronary atherosclerosis in men and women in the recent general Japanese population, we examined coronary arteries obtained from subjects autopsied in the Hisayama cohort study (autopsy rate: 78.7%). The subjects were over 40 years of age and consisted of 125 men and 108 women. They underwent an antemortem medical examination in 1988 and were subject to autopsy at death during an 8-year follow-up period. Atherosclerosis was globally assessed by examining 14 specimens taken from wide areas of epicardial coronary arteries and classified into 6 grades. The frequency of more severe grades of coronary atherosclerosis increased with age in both genders and was greater in men than in women of the same age. Multiple regression analysis revealed that age, systolic blood pressure, serum total cholesterol, and hemoglobin A1C were significant risk factors for men. Age, systolic blood pressure, and waist to hip ratio were risk factors for women. Smoking was not significantly correlated with the grade of coronary atherosclerosis in either gender. Thus, aging, hypertension, hypercholesterolemia, obesity, and glucose intolerance are risk factors for coronary atherosclerosis in recent Japanese populations, and the significance of the metabolic risk factors is different between men and women.
AB - To investigate risk factors for coronary atherosclerosis in men and women in the recent general Japanese population, we examined coronary arteries obtained from subjects autopsied in the Hisayama cohort study (autopsy rate: 78.7%). The subjects were over 40 years of age and consisted of 125 men and 108 women. They underwent an antemortem medical examination in 1988 and were subject to autopsy at death during an 8-year follow-up period. Atherosclerosis was globally assessed by examining 14 specimens taken from wide areas of epicardial coronary arteries and classified into 6 grades. The frequency of more severe grades of coronary atherosclerosis increased with age in both genders and was greater in men than in women of the same age. Multiple regression analysis revealed that age, systolic blood pressure, serum total cholesterol, and hemoglobin A1C were significant risk factors for men. Age, systolic blood pressure, and waist to hip ratio were risk factors for women. Smoking was not significantly correlated with the grade of coronary atherosclerosis in either gender. Thus, aging, hypertension, hypercholesterolemia, obesity, and glucose intolerance are risk factors for coronary atherosclerosis in recent Japanese populations, and the significance of the metabolic risk factors is different between men and women.
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U2 - 10.1016/j.prp.2009.05.002
DO - 10.1016/j.prp.2009.05.002
M3 - Article
C2 - 19493634
AN - SCOPUS:70249146481
SN - 0344-0338
VL - 205
SP - 700
EP - 708
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 10
ER -