Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture.

Yoshinobu Kondo, Hideaki Toyoshima, Hiroshi Yatsuya, Kaoru Hirose, Yasuji Morikawa, Naohiro Ikedo, Tsuneo Masui, Koji Tamakoshi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recently, in Western countries, metabolic syndrome as well as such classical risk factors as hypertension and smoking has been considered to be closely associated with the occurrence of acute myocardial infarction (AMI). Therefore, we conducted a case-control study to investigate how the co-morbidity of obesity or thinness with hypertension, hyperlipidemia and diabetes mellitus would affect AMI occurrence among Japanese aged 30 to 69. Cases were comprised of 788 patients (590 men and 198 women) registered in the "Aichi Prefecture Cardiovascular Disease Registry Program" during hospitalization due to their first AMI attack. Controls were 2,300 randomly sampled inhabitants (1,142 men and 1,158 women) who responded to the questionnaire survey on lifestyle. We decided BMI < 18.5 as thin, 18.5 < or = BMI < 25.0 as normal, and BMI > or = 25.0 as obese, then divided subjects into six groups according to the presence or absence of histories of the above-mentioned three diseases in connection with their physique. In both sexes, multivariately adjusted odds ratios of first AMI attacks were much higher in groups with such histories (men, 4.14 to approximately 5.07; women, 5.62 to approximately 15.24) than in those without them (men, 0.90 to approximately 1.13; women, 1.54 to approximately 3.03) regardless of physique. Only in women, obesity uncombined with histories was significantly associated with AMI occurrence and not obesity but thinness intensified the association between histories and AMI. Among the six groups, population attributable risk percent was highest in the normal physique group with histories. It was suggested that persons with disease histories should be carefully treated irrespective of the presence or absence of obesity.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalNagoya Journal of Medical Science
Volume69
Issue number3-4
Publication statusPublished - 01-01-2007
Externally publishedYes

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Registries
Cardiovascular Diseases
Myocardial Infarction
Obesity
Thinness
Hypertension
Hyperlipidemias
Population Groups
Case-Control Studies
Life Style
Diabetes Mellitus
Hospitalization
Smoking
Odds Ratio
Morbidity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kondo, Yoshinobu ; Toyoshima, Hideaki ; Yatsuya, Hiroshi ; Hirose, Kaoru ; Morikawa, Yasuji ; Ikedo, Naohiro ; Masui, Tsuneo ; Tamakoshi, Koji. / Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. In: Nagoya Journal of Medical Science. 2007 ; Vol. 69, No. 3-4. pp. 139-147.
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Kondo, Y, Toyoshima, H, Yatsuya, H, Hirose, K, Morikawa, Y, Ikedo, N, Masui, T & Tamakoshi, K 2007, 'Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture.', Nagoya Journal of Medical Science, vol. 69, no. 3-4, pp. 139-147.

Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. / Kondo, Yoshinobu; Toyoshima, Hideaki; Yatsuya, Hiroshi; Hirose, Kaoru; Morikawa, Yasuji; Ikedo, Naohiro; Masui, Tsuneo; Tamakoshi, Koji.

In: Nagoya Journal of Medical Science, Vol. 69, No. 3-4, 01.01.2007, p. 139-147.

Research output: Contribution to journalArticle

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AU - Kondo, Yoshinobu

AU - Toyoshima, Hideaki

AU - Yatsuya, Hiroshi

AU - Hirose, Kaoru

AU - Morikawa, Yasuji

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AU - Masui, Tsuneo

AU - Tamakoshi, Koji

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AB - Recently, in Western countries, metabolic syndrome as well as such classical risk factors as hypertension and smoking has been considered to be closely associated with the occurrence of acute myocardial infarction (AMI). Therefore, we conducted a case-control study to investigate how the co-morbidity of obesity or thinness with hypertension, hyperlipidemia and diabetes mellitus would affect AMI occurrence among Japanese aged 30 to 69. Cases were comprised of 788 patients (590 men and 198 women) registered in the "Aichi Prefecture Cardiovascular Disease Registry Program" during hospitalization due to their first AMI attack. Controls were 2,300 randomly sampled inhabitants (1,142 men and 1,158 women) who responded to the questionnaire survey on lifestyle. We decided BMI < 18.5 as thin, 18.5 < or = BMI < 25.0 as normal, and BMI > or = 25.0 as obese, then divided subjects into six groups according to the presence or absence of histories of the above-mentioned three diseases in connection with their physique. In both sexes, multivariately adjusted odds ratios of first AMI attacks were much higher in groups with such histories (men, 4.14 to approximately 5.07; women, 5.62 to approximately 15.24) than in those without them (men, 0.90 to approximately 1.13; women, 1.54 to approximately 3.03) regardless of physique. Only in women, obesity uncombined with histories was significantly associated with AMI occurrence and not obesity but thinness intensified the association between histories and AMI. Among the six groups, population attributable risk percent was highest in the normal physique group with histories. It was suggested that persons with disease histories should be carefully treated irrespective of the presence or absence of obesity.

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