Risk factors for multiple myeloma: Evidence from the Japan collaborative cohort (JACC) study

M. M.H. Khan, Mitsuru Mori, Fumio Sakauchi, Keitaro Matsuo, Kotaro Ozasa, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Kenji Wakai, Shinkan Tokudome, Yoshinori ItoShuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Takashi Shimamoto, Heizo Tanaka, Shigeru Hisamichi, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Teruo Ishibashi, Katsuhiro Fukuda

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Abstract

This study assessed the association of multiple myeloma (MM) with age, body mass index (BMI, kg/m2), physical activity, occupational history, and medical history for a Japanese cohort of 46,157 men and 63,541 women aged 40-79 years followed during 1988-2003 years. Cox proportional hazard model was mainly used to estimate the age and sex adjusted hazard ratio (HR) of MM including 95% confidence interval (CI) for both sexes. Same model, adjusted for age, was also used for each sex. In total, 98 MM deaths (men=49 and women=49) was observed for both sexes. Higher age groups (60-69 and 70-79 years) experienced significantly higher unadjusted HR of MM than the age group of 40-49 years. Men revealed significantly higher age-adjusted MM than women (HR=1.5; 95% CI=1.0-2.2). For both sexes, higher BMI of ≥30 kg/m2 (HR=2.8; 95% CI=1.0-7.7), walking ≤30 minutes/day (HR=2.0; 95% CI=1.2-3.4), worried about personal relationship in working place (HR=2.3; 95% CI=1.3-4.2), restricted own pace in working place (HR=1.9; 95% CI=1.0-3.4), and history of peptic ulcer (HR=1.7; 95% CI=1.0-2.7) significantly increased age and sex adjusted MM risk. Some of the above-mentioned significant associations became insignificant for age adjusted sex specific analyses. However, these findings should be validated by further epidemiologic studies in Japan before generalization.

Original languageEnglish
Pages (from-to)575-581
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Volume7
Issue number4
Publication statusPublished - 01-01-2006

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All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Khan, M. M. H., Mori, M., Sakauchi, F., Matsuo, K., Ozasa, K., Tamakoshi, A., Mori, M., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Inaba, Y., Hoshiyama, Y., Suzuki, H., Shimizu, H., Toyoshima, H., Wakai, K., Tokudome, S., ... Fukuda, K. (2006). Risk factors for multiple myeloma: Evidence from the Japan collaborative cohort (JACC) study. Asian Pacific Journal of Cancer Prevention, 7(4), 575-581.