Risk factors for multiple myeloma

Evidence from the Japan collaborative cohort (JACC) study

M. M.H. Khan, Mitsuru Mori, Fumio Sakauchi, Keitaro Matsuo, Kotaro Ozasa, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Kenji Wakai, Shinkan Tokudome, Yoshinori Ito & 26 others Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Takashi Shimamoto, Heizo Tanaka, Shigeru Hisamichi, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Teruo Ishibashi, Katsuhiro Fukuda

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This study assessed the association of multiple myeloma (MM) with age, body mass index (BMI, kg/m2), physical activity, occupational history, and medical history for a Japanese cohort of 46,157 men and 63,541 women aged 40-79 years followed during 1988-2003 years. Cox proportional hazard model was mainly used to estimate the age and sex adjusted hazard ratio (HR) of MM including 95% confidence interval (CI) for both sexes. Same model, adjusted for age, was also used for each sex. In total, 98 MM deaths (men=49 and women=49) was observed for both sexes. Higher age groups (60-69 and 70-79 years) experienced significantly higher unadjusted HR of MM than the age group of 40-49 years. Men revealed significantly higher age-adjusted MM than women (HR=1.5; 95% CI=1.0-2.2). For both sexes, higher BMI of ≥30 kg/m2 (HR=2.8; 95% CI=1.0-7.7), walking ≤30 minutes/day (HR=2.0; 95% CI=1.2-3.4), worried about personal relationship in working place (HR=2.3; 95% CI=1.3-4.2), restricted own pace in working place (HR=1.9; 95% CI=1.0-3.4), and history of peptic ulcer (HR=1.7; 95% CI=1.0-2.7) significantly increased age and sex adjusted MM risk. Some of the above-mentioned significant associations became insignificant for age adjusted sex specific analyses. However, these findings should be validated by further epidemiologic studies in Japan before generalization.

Original languageEnglish
Pages (from-to)575-581
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Volume7
Issue number4
Publication statusPublished - 01-01-2006

Fingerprint

Multiple Myeloma
Japan
Cohort Studies
Confidence Intervals
Age Groups
Peptic Ulcer
Proportional Hazards Models
Walking
Epidemiologic Studies
Body Mass Index
Exercise

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Khan, M. M. H., Mori, M., Sakauchi, F., Matsuo, K., Ozasa, K., Tamakoshi, A., ... Fukuda, K. (2006). Risk factors for multiple myeloma: Evidence from the Japan collaborative cohort (JACC) study. Asian Pacific Journal of Cancer Prevention, 7(4), 575-581.
Khan, M. M.H. ; Mori, Mitsuru ; Sakauchi, Fumio ; Matsuo, Keitaro ; Ozasa, Kotaro ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Wakai, Kenji ; Tokudome, Shinkan ; Ito, Yoshinori ; Hashimoto, Shuji ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo ; Shimamoto, Takashi ; Tanaka, Heizo ; Hisamichi, Shigeru ; Nakao, Masahiro ; Suzuki, Takaichiro ; Hashimoto, Tsutomu ; Ishibashi, Teruo ; Fukuda, Katsuhiro. / Risk factors for multiple myeloma : Evidence from the Japan collaborative cohort (JACC) study. In: Asian Pacific Journal of Cancer Prevention. 2006 ; Vol. 7, No. 4. pp. 575-581.
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abstract = "This study assessed the association of multiple myeloma (MM) with age, body mass index (BMI, kg/m2), physical activity, occupational history, and medical history for a Japanese cohort of 46,157 men and 63,541 women aged 40-79 years followed during 1988-2003 years. Cox proportional hazard model was mainly used to estimate the age and sex adjusted hazard ratio (HR) of MM including 95{\%} confidence interval (CI) for both sexes. Same model, adjusted for age, was also used for each sex. In total, 98 MM deaths (men=49 and women=49) was observed for both sexes. Higher age groups (60-69 and 70-79 years) experienced significantly higher unadjusted HR of MM than the age group of 40-49 years. Men revealed significantly higher age-adjusted MM than women (HR=1.5; 95{\%} CI=1.0-2.2). For both sexes, higher BMI of ≥30 kg/m2 (HR=2.8; 95{\%} CI=1.0-7.7), walking ≤30 minutes/day (HR=2.0; 95{\%} CI=1.2-3.4), worried about personal relationship in working place (HR=2.3; 95{\%} CI=1.3-4.2), restricted own pace in working place (HR=1.9; 95{\%} CI=1.0-3.4), and history of peptic ulcer (HR=1.7; 95{\%} CI=1.0-2.7) significantly increased age and sex adjusted MM risk. Some of the above-mentioned significant associations became insignificant for age adjusted sex specific analyses. However, these findings should be validated by further epidemiologic studies in Japan before generalization.",
author = "Khan, {M. M.H.} and Mitsuru Mori and Fumio Sakauchi and Keitaro Matsuo and Kotaro Ozasa and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Kenji Wakai and Shinkan Tokudome and Yoshinori Ito and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima and Takashi Shimamoto and Heizo Tanaka and Shigeru Hisamichi and Masahiro Nakao and Takaichiro Suzuki and Tsutomu Hashimoto and Teruo Ishibashi and Katsuhiro Fukuda",
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Khan, MMH, Mori, M, Sakauchi, F, Matsuo, K, Ozasa, K, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Wakai, K, Tokudome, S, Ito, Y, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T, Tajima, K, Shimamoto, T, Tanaka, H, Hisamichi, S, Nakao, M, Suzuki, T, Hashimoto, T, Ishibashi, T & Fukuda, K 2006, 'Risk factors for multiple myeloma: Evidence from the Japan collaborative cohort (JACC) study', Asian Pacific Journal of Cancer Prevention, vol. 7, no. 4, pp. 575-581.

Risk factors for multiple myeloma : Evidence from the Japan collaborative cohort (JACC) study. / Khan, M. M.H.; Mori, Mitsuru; Sakauchi, Fumio; Matsuo, Keitaro; Ozasa, Kotaro; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Wakai, Kenji; Tokudome, Shinkan; Ito, Yoshinori; Hashimoto, Shuji; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo; Shimamoto, Takashi; Tanaka, Heizo; Hisamichi, Shigeru; Nakao, Masahiro; Suzuki, Takaichiro; Hashimoto, Tsutomu; Ishibashi, Teruo; Fukuda, Katsuhiro.

In: Asian Pacific Journal of Cancer Prevention, Vol. 7, No. 4, 01.01.2006, p. 575-581.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for multiple myeloma

T2 - Evidence from the Japan collaborative cohort (JACC) study

AU - Khan, M. M.H.

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Matsuo, Keitaro

AU - Ozasa, Kotaro

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

AU - Shimamoto, Takashi

AU - Tanaka, Heizo

AU - Hisamichi, Shigeru

AU - Nakao, Masahiro

AU - Suzuki, Takaichiro

AU - Hashimoto, Tsutomu

AU - Ishibashi, Teruo

AU - Fukuda, Katsuhiro

PY - 2006/1/1

Y1 - 2006/1/1

N2 - This study assessed the association of multiple myeloma (MM) with age, body mass index (BMI, kg/m2), physical activity, occupational history, and medical history for a Japanese cohort of 46,157 men and 63,541 women aged 40-79 years followed during 1988-2003 years. Cox proportional hazard model was mainly used to estimate the age and sex adjusted hazard ratio (HR) of MM including 95% confidence interval (CI) for both sexes. Same model, adjusted for age, was also used for each sex. In total, 98 MM deaths (men=49 and women=49) was observed for both sexes. Higher age groups (60-69 and 70-79 years) experienced significantly higher unadjusted HR of MM than the age group of 40-49 years. Men revealed significantly higher age-adjusted MM than women (HR=1.5; 95% CI=1.0-2.2). For both sexes, higher BMI of ≥30 kg/m2 (HR=2.8; 95% CI=1.0-7.7), walking ≤30 minutes/day (HR=2.0; 95% CI=1.2-3.4), worried about personal relationship in working place (HR=2.3; 95% CI=1.3-4.2), restricted own pace in working place (HR=1.9; 95% CI=1.0-3.4), and history of peptic ulcer (HR=1.7; 95% CI=1.0-2.7) significantly increased age and sex adjusted MM risk. Some of the above-mentioned significant associations became insignificant for age adjusted sex specific analyses. However, these findings should be validated by further epidemiologic studies in Japan before generalization.

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Khan MMH, Mori M, Sakauchi F, Matsuo K, Ozasa K, Tamakoshi A et al. Risk factors for multiple myeloma: Evidence from the Japan collaborative cohort (JACC) study. Asian Pacific Journal of Cancer Prevention. 2006 Jan 1;7(4):575-581.