TY - JOUR
T1 - Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy
AU - Souma, Tomohide
AU - Minezawa, Tomoyuki
AU - Yatsuya, Hiroshi
AU - Okamura, Takuya
AU - Yamatsuta, Kumiko
AU - Morikawa, Sayako
AU - Horiguchi, Tomoya
AU - Maeda, Shingo
AU - Goto, Yasuhiro
AU - Hayashi, Masamichi
AU - Isogai, Sumito
AU - Yamamoto, Naoki
AU - Kondo, Masashi
AU - Imaizumi, Kazuyoshi
N1 - Funding Information:
Author contributions: K. I. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. T. S. T. M. T. O. and K. I. contributed to the conception and design of the study protocol; collection, analysis, and interpretation of the data; drafting and revision of the manuscript; and generation of the tables. H. Y. contributed to all statistical analysis of the data. N. Y. contributed to the revision of the manuscript. K. Y. and S. Morikawa contributed to the collection and interpretation of the data, and generation of figures. T. H. S. Maeda, and Y. G. contributed to the analysis of data and generating tables. M. H. and S. I. contributed to design of the study protocol and revision of the manuscript. M. K. contributed to the drafting and revision of the manuscript. All authors approved the final manuscript. Financial/nonfinancial disclosures: None declared. Other contributions: We thank Ms Naomi Maeda for her excellent secretarial support. We also thank Ms Chieko Oka and Ms Noriko Hiramatsu for their technical support. We thank Hugh McGonigle, from Edanz Group (www.edanzediting.com/ac), for editing a draft of the manuscript. FUNDING/SUPPORT: The authors have reported to CHEST that no funding was received for this study.
PY - 2020/8
Y1 - 2020/8
N2 - Background: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. Research Question: What are the risk factors for infection after EBUS-GS-TBB? Study Design and Methods: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). Results: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. Interpretation: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.
AB - Background: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. Research Question: What are the risk factors for infection after EBUS-GS-TBB? Study Design and Methods: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). Results: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. Interpretation: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.
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U2 - 10.1016/j.chest.2020.02.025
DO - 10.1016/j.chest.2020.02.025
M3 - Article
C2 - 32145245
AN - SCOPUS:85086047632
VL - 158
SP - 797
EP - 807
JO - Chest
JF - Chest
SN - 0012-3692
IS - 2
ER -