Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan

M. M.H. Khan; Mitsuru Mori; Fumio Sakauchi; Khandoker Aklimunnessa; Tatsuhiko Kubo; Yoshihisa Fujino; Sadao Suzuki; Shinkan Tokudome; Akiko Tamakoshi; Yutaka Motohashi; Ichiro Tsuji; Yosikazu Nakamura; Hiroyasu Iso; Haruo Mikami; Yutaka Inaba; Yoshiharu Hoshiyama; Hiroshi Suzuki; Hiroyuki Shimizu; Hideaki Toyoshima; Kenji Wakai; Yoshinori Ito; Shuji Hashimoto; Shogo Kikuchi; Akio Koizumi; Takashi Kawamura; Yoshiyuki Watanabe; Tsuneharu Miki; Chigusa Date; Kiyomi Sakata; Takayuki Nose; Norihiko Hayakawa; Takesumi Yoshimura; Akira Shibata; Naoyuki Okamoto; Hideo Shio; Yoshiyuki Ohno; Tomoyuki Kitagawa; Toshio Kuroki; Kazuo Tajima; Takashi Shimamoto; Heizo Tanaka; Shigeru Hisamichi; Masahiro Nakao; Takaichiro Suzuki; Tsutomu Hashimoto; Teruo Ishibashi; Katsuhiro Fukuda

Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan

M. M.H. Khan, Mitsuru Mori, Fumio Sakauchi, Khandoker Aklimunnessa, Tatsuhiko Kubo, Yoshihisa Fujino, Sadao Suzuki, Shinkan Tokudome, Akiko Tamakoshi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Kenji WakaiYoshinori Ito, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Takashi Shimamoto, Heizo Tanaka, Shigeru Hisamichi, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Teruo Ishibashi, Katsuhiro Fukuda

Hygiene

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Objectives: To examine associations of ever-use of sex hormones (EUSH) and other factors with endometrial cancer (EC) mortality through a nation-wide Japan Collaborative Cohort Study. Methods: A total of 63,541 women aged 40-79 years, enrolled in 1988-90 from 45 municipalities of Japan, were followed until 2003 to record their vital status. Using baseline data, the Cox proportional hazard model (age adjusted and multivariate) was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for EC mortality by selected factors, including EUSH. Bivariate analysis was also conducted to establish associations between EUSH and other factors. Results: The mortality rate from EC was 2.6 per 100,000 person-years during the mean follow-up period of 13.3 years. Prevalence rate of EUSH was 5.2%. Significantly increased risk of EC mortality was found for EUSH with both age adjusted (HR=6.43, 95%CI=2.10-19.67) and multivariate (HR=5.33; 95%CI=1.51-18.82) analyses. Bivariate analysis indicated that history of diabetes mellitus, smoking, drinking, and age at first delivery were positively associated with EUSH, whereas age, number of delivery, number of pregnancy, and age at menarche demonstrated inverse links. Conclusions: Our results imply that EUSH may increase the risk of EC mortality among Japanese women. However, further studies with more deaths are needed to validate the results.

Original language	English
Pages (from-to)	260-266
Number of pages	7
Journal	Asian Pacific Journal of Cancer Prevention
Volume	7
Issue number	2
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Epidemiology
Oncology
Public Health, Environmental and Occupational Health
Cancer Research

Cite this

Khan, M. M. H., Mori, M., Sakauchi, F., Aklimunnessa, K., Kubo, T., Fujino, Y., Suzuki, S., Tokudome, S., Tamakoshi, A., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Inaba, Y., Hoshiyama, Y., Suzuki, H., Shimizu, H., Toyoshima, H., ... Fukuda, K. (2006). Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan. Asian Pacific Journal of Cancer Prevention, 7(2), 260-266.

@article{d4e6ef3ba346489b96c44281f9748c39,

title = "Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan",

abstract = "Objectives: To examine associations of ever-use of sex hormones (EUSH) and other factors with endometrial cancer (EC) mortality through a nation-wide Japan Collaborative Cohort Study. Methods: A total of 63,541 women aged 40-79 years, enrolled in 1988-90 from 45 municipalities of Japan, were followed until 2003 to record their vital status. Using baseline data, the Cox proportional hazard model (age adjusted and multivariate) was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for EC mortality by selected factors, including EUSH. Bivariate analysis was also conducted to establish associations between EUSH and other factors. Results: The mortality rate from EC was 2.6 per 100,000 person-years during the mean follow-up period of 13.3 years. Prevalence rate of EUSH was 5.2%. Significantly increased risk of EC mortality was found for EUSH with both age adjusted (HR=6.43, 95%CI=2.10-19.67) and multivariate (HR=5.33; 95%CI=1.51-18.82) analyses. Bivariate analysis indicated that history of diabetes mellitus, smoking, drinking, and age at first delivery were positively associated with EUSH, whereas age, number of delivery, number of pregnancy, and age at menarche demonstrated inverse links. Conclusions: Our results imply that EUSH may increase the risk of EC mortality among Japanese women. However, further studies with more deaths are needed to validate the results.",

author = "Khan, {M. M.H.} and Mitsuru Mori and Fumio Sakauchi and Khandoker Aklimunnessa and Tatsuhiko Kubo and Yoshihisa Fujino and Sadao Suzuki and Shinkan Tokudome and Akiko Tamakoshi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Kenji Wakai and Yoshinori Ito and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima and Takashi Shimamoto and Heizo Tanaka and Shigeru Hisamichi and Masahiro Nakao and Takaichiro Suzuki and Tsutomu Hashimoto and Teruo Ishibashi and Katsuhiro Fukuda",

year = "2006",

language = "English",

volume = "7",

pages = "260--266",

journal = "Asian Pacific Journal of Cancer Prevention",

issn = "1513-7368",

publisher = "Asian Pacific Organization for Cancer Prevention",

number = "2",

}

Khan, MMH, Mori, M, Sakauchi, F, Aklimunnessa, K, Kubo, T, Fujino, Y, Suzuki, S, Tokudome, S, Tamakoshi, A, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Wakai, K, Ito, Y, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T, Tajima, K, Shimamoto, T, Tanaka, H, Hisamichi, S, Nakao, M, Suzuki, T, Hashimoto, T, Ishibashi, T & Fukuda, K 2006, 'Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan', Asian Pacific Journal of Cancer Prevention, vol. 7, no. 2, pp. 260-266.

TY - JOUR

T1 - Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan

AU - Khan, M. M.H.

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Aklimunnessa, Khandoker

AU - Kubo, Tatsuhiko

AU - Fujino, Yoshihisa

AU - Suzuki, Sadao

AU - Tokudome, Shinkan

AU - Tamakoshi, Akiko

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Wakai, Kenji

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

AU - Shimamoto, Takashi

AU - Tanaka, Heizo

AU - Hisamichi, Shigeru

AU - Nakao, Masahiro

AU - Suzuki, Takaichiro

AU - Hashimoto, Tsutomu

AU - Ishibashi, Teruo

AU - Fukuda, Katsuhiro

PY - 2006

Y1 - 2006

N2 - Objectives: To examine associations of ever-use of sex hormones (EUSH) and other factors with endometrial cancer (EC) mortality through a nation-wide Japan Collaborative Cohort Study. Methods: A total of 63,541 women aged 40-79 years, enrolled in 1988-90 from 45 municipalities of Japan, were followed until 2003 to record their vital status. Using baseline data, the Cox proportional hazard model (age adjusted and multivariate) was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for EC mortality by selected factors, including EUSH. Bivariate analysis was also conducted to establish associations between EUSH and other factors. Results: The mortality rate from EC was 2.6 per 100,000 person-years during the mean follow-up period of 13.3 years. Prevalence rate of EUSH was 5.2%. Significantly increased risk of EC mortality was found for EUSH with both age adjusted (HR=6.43, 95%CI=2.10-19.67) and multivariate (HR=5.33; 95%CI=1.51-18.82) analyses. Bivariate analysis indicated that history of diabetes mellitus, smoking, drinking, and age at first delivery were positively associated with EUSH, whereas age, number of delivery, number of pregnancy, and age at menarche demonstrated inverse links. Conclusions: Our results imply that EUSH may increase the risk of EC mortality among Japanese women. However, further studies with more deaths are needed to validate the results.

AB - Objectives: To examine associations of ever-use of sex hormones (EUSH) and other factors with endometrial cancer (EC) mortality through a nation-wide Japan Collaborative Cohort Study. Methods: A total of 63,541 women aged 40-79 years, enrolled in 1988-90 from 45 municipalities of Japan, were followed until 2003 to record their vital status. Using baseline data, the Cox proportional hazard model (age adjusted and multivariate) was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for EC mortality by selected factors, including EUSH. Bivariate analysis was also conducted to establish associations between EUSH and other factors. Results: The mortality rate from EC was 2.6 per 100,000 person-years during the mean follow-up period of 13.3 years. Prevalence rate of EUSH was 5.2%. Significantly increased risk of EC mortality was found for EUSH with both age adjusted (HR=6.43, 95%CI=2.10-19.67) and multivariate (HR=5.33; 95%CI=1.51-18.82) analyses. Bivariate analysis indicated that history of diabetes mellitus, smoking, drinking, and age at first delivery were positively associated with EUSH, whereas age, number of delivery, number of pregnancy, and age at menarche demonstrated inverse links. Conclusions: Our results imply that EUSH may increase the risk of EC mortality among Japanese women. However, further studies with more deaths are needed to validate the results.

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UR - http://www.scopus.com/inward/citedby.url?scp=33748470791&partnerID=8YFLogxK

M3 - Article

C2 - 16839220

AN - SCOPUS:33748470791

SN - 1513-7368

VL - 7

SP - 260

EP - 266

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

IS - 2

ER -

Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan

Abstract

All Science Journal Classification (ASJC) codes

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