Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarcts

Aaron R. Folsom, Hiroshi Yatsuya, Thomas H. Mosley, Bruce M. Psaty, W. T. Longstreth

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To determine whether the burden of leukoaraiosis and the number of brain infarcts, defined by magnetic resonance imaging (MRI), are prospectively and independently associated with intraparenchymal hemorrhage (IPH) incidence in a pooled population-based study. Methods: Among 4,872 participants initially free of clinical stroke in the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study, we assessed white matter grade (range, 0-9), reflecting increasing leukoaraiosis, and brain infarcts using MRI. Over a median of 13 years of follow-up, 71 incident, spontaneous IPH events occurred. Results: After adjustment for other IPH risk factors, the hazard ratios (95% confidence intervals) across white matter grades 0 to 1, 2, 3, and 4 to 9 were 1.00, 1.68 (0.86-3.30), 3.52 (1.80-6.89), and 3.96 (1.90-8.27), respectively (p for trend <0.0001). These hazard ratios were weakened only modestly (p for trend = 0.0003) with adjustment for MRI-defined brain infarcts. The IPH hazard ratios for 0, 1, 2, or ≥3 MRI-defined brain infarcts were 1.00, 1.97 (1.10-3.54), 2.00 (0.83-4.78), and 3.12 (1.31-7.43) (p for trend = 0.002), but these were substantially attenuated when adjusted for white matter grade (p for trend = 0.049). Interpretation: Greater MRI-defined burden of leukoaraiosis is a risk factor for spontaneous IPH. Spontaneous IPH should be added to the growing list of potential poor outcomes in people with leukoaraiosis.

Original languageEnglish
Pages (from-to)552-559
Number of pages8
JournalAnnals of Neurology
Volume71
Issue number4
DOIs
Publication statusPublished - 01-04-2012
Externally publishedYes

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Leukoaraiosis
Magnetic Resonance Imaging
Hemorrhage
Brain
Atherosclerosis
Stroke
Confidence Intervals
Incidence
Health
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Folsom, Aaron R. ; Yatsuya, Hiroshi ; Mosley, Thomas H. ; Psaty, Bruce M. ; Longstreth, W. T. / Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarcts. In: Annals of Neurology. 2012 ; Vol. 71, No. 4. pp. 552-559.
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Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarcts. / Folsom, Aaron R.; Yatsuya, Hiroshi; Mosley, Thomas H.; Psaty, Bruce M.; Longstreth, W. T.

In: Annals of Neurology, Vol. 71, No. 4, 01.04.2012, p. 552-559.

Research output: Contribution to journalArticle

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