TY - JOUR
T1 - Ritipenem acoxil, a new oral penem antibiotic, in urogenital infection
AU - Suzuki, Keizo
AU - Horiba, Masaki
AU - Ishikawa, Kiyohito
AU - Katoh, Shinobu
AU - Naide, Yorio
AU - Yanaoka, Masanori
AU - Tanaka, Toshiyuki
PY - 1995
Y1 - 1995
N2 - The following results were obtained for a new oral penem antibiotic, ritipenem acoxil (RIPMAC). 1. Diffusion into human prostatic fluid The concentration of ritipenem (RIPM) in the prostatic fluid at 1 hour after administration of 400 mg RIPM-AC was less than 0.08 μg/ml in all of 4 human prostatic fluid specimens tested. 2. Clinical study on UTI The drug was given at daily doses of 450-600 mg divided into 3 times, for a period of 3-7 days in 24 patients with UTI. According to the Japanese UTI Committee's criteria, the efficacy on 17 patients with chronic complicated urinary tract infection was excellent in 11 patients, moderate in 4 and poor in 2, thus, a response rate being 88.2%. As for side effect, stomach discomfort was found in one patient. There were no particular significant abnormal laboratory values.
AB - The following results were obtained for a new oral penem antibiotic, ritipenem acoxil (RIPMAC). 1. Diffusion into human prostatic fluid The concentration of ritipenem (RIPM) in the prostatic fluid at 1 hour after administration of 400 mg RIPM-AC was less than 0.08 μg/ml in all of 4 human prostatic fluid specimens tested. 2. Clinical study on UTI The drug was given at daily doses of 450-600 mg divided into 3 times, for a period of 3-7 days in 24 patients with UTI. According to the Japanese UTI Committee's criteria, the efficacy on 17 patients with chronic complicated urinary tract infection was excellent in 11 patients, moderate in 4 and poor in 2, thus, a response rate being 88.2%. As for side effect, stomach discomfort was found in one patient. There were no particular significant abnormal laboratory values.
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U2 - 10.11250/chemotherapy1995.43.Supplement3_236
DO - 10.11250/chemotherapy1995.43.Supplement3_236
M3 - Article
AN - SCOPUS:0028828050
SN - 1340-7007
VL - 43
SP - 236
EP - 241
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
ER -