Role of CD86 (B7-2) in triggering of antigen-specific IgE antibody response by lipopolysaccharide

G. Z. Jiang, Y. Kato, T. Sugiyama, N. Koide, D. Chakravortty, M. Kawai, M. Fukada, T. Yoshida, T. Yokochi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The role of CD86 in triggering of ascaris extract-specific IgE antibody response by lipopolysaccharide was studied. The simultaneous administration of anti-CD86 antibody with ascaris extract and lipopolysaccharide prevented the production of IgE antibody response to ascaris extract. CD86+ cells were detected in peritoneal cavities and spleens of mice injected intraperitoneally with lipopolysaccharide. CD86+ cells appeared in peritoneal cavities and spleens eight hours after lipopolysaccharide injection, and they were detectable for a week. CD86+ cells in peritoneal cavities and spleens were mainly surface Ig-positive B-cells and some Ig-negative cells. It was suggested that lipopolysaccharide induced the expression of CD86 mainly on B-cells, and that CD86+ cells induced by lipopolysaccharide injection might play an important role as antigen-presenting cells on triggering of ascaris extract-specific IgE antibody response by lipopolysaccharide. Copyright (C) 1998 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalFEMS Immunology and Medical Microbiology
Volume21
Issue number4
DOIs
Publication statusPublished - 08-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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