Role of circulating free Alu DNA in endometrial cancer

Hideo Tanaka, Hiroshi Tsuda, Sadako Nishimura, Hiroyuki Nomura, Fumio Kataoka, Tatsuyuki Chiyoda, Kyoko Tanaka, Yoko Iguchi, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: Endometrial cancer (EC) is the most common cancer of the female genital tract. However, no screening method for EC has been established yet. In this study, we evaluated the cell-free DNA in EC. Methods: Fifteen healthy individuals, 9 with benign gynecologic diseases, and 53 with ECs were included in this study. Alu sequences in free DNA fragments were used as surrogate markers, and cell-free DNA density was measured by quantitative real-time polymerase chain reaction. Results: The cell-free DNA levels in ECs tended to be higher than in benign condition (healthy individuals + benign gynecologic diseases, n = 24; P = 0.095). There was no significant difference in cell-free DNA among stage or histological grade of EC, and no significant change in cell-free DNA before and after operation (P = 0.25): Moreover, in 19 ECs, cell-free DNA decreased after operation, however, in 6 ECs, cell-free DNA did not decrease. Three ECs recurred, and cell-free DNA did not decrease in these cases. Conclusions: Measurement of cell-free DNA is not useful for EC screening; however, the change of cell-free DNA in a patient may be a prognostic biomarker of EC.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume22
Issue number1
DOIs
Publication statusPublished - 01-2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

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