TY - CHAP
T1 - Role of computational fluid dynamics for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
T2 - Study protocol for a multicenter prospective study
AU - CFD3 Study Group
AU - Shiba, Masato
AU - Ishida, Fujimaro
AU - Miya, Fumitaka
AU - Araki, Tomohiro
AU - Mase, Mitsuhito
AU - Kurita, Hiroki
AU - Kasuya, Hidetoshi
AU - Yamamoto, Takuji
AU - Kato, Yoko
AU - Iwabuchi, Satoshi
AU - Suzuki, Hidenori
AU - Yasuda, Ryuta
AU - Toma, Naoki
AU - Okada, Takeshi
AU - Nishikawa, Hirofumi
AU - Miura, Yoichi
AU - Tanemura, Hiroshi
AU - Nakatsuka, Yoshinari
AU - Nishikawa, Yusuke
AU - Kikkawa, Yuichiro
AU - Ohbuchi, Hidenori
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2020.
PY - 2020
Y1 - 2020
N2 - Background: Delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Recently, we reported the possibility that computational fluid dynamics (CFD) could predict DCI in terms of the cross-sectional area and flow velocity of the ipsilateral extracranial internal carotid and distal parent arteries in a single-center retrospective study. Methods: This is a multicenter, prospective, cohort study. Patients with aneurysmal SAH will undergo CFD analyses using preoperative three-dimensional computed tomography angiography, and we will investigate hemodynamic features of cerebral arteries in an acute stage of SAH. Primary outcome measures will be CFD features in patients with subsequent occurrence of DCI. Secondary outcome measures will be CFD features in patients with subsequent occurrence of cerebral vasospasm and cerebral infarction and the relationships with eventual modified Rankin scale score at 3 months. Conclusions: The present protocol for a multicenter prospective study is expected to provide a novel diagnostic method to predict DCI before aneurysmal obliteration in an acute stage of SAH.
AB - Background: Delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Recently, we reported the possibility that computational fluid dynamics (CFD) could predict DCI in terms of the cross-sectional area and flow velocity of the ipsilateral extracranial internal carotid and distal parent arteries in a single-center retrospective study. Methods: This is a multicenter, prospective, cohort study. Patients with aneurysmal SAH will undergo CFD analyses using preoperative three-dimensional computed tomography angiography, and we will investigate hemodynamic features of cerebral arteries in an acute stage of SAH. Primary outcome measures will be CFD features in patients with subsequent occurrence of DCI. Secondary outcome measures will be CFD features in patients with subsequent occurrence of cerebral vasospasm and cerebral infarction and the relationships with eventual modified Rankin scale score at 3 months. Conclusions: The present protocol for a multicenter prospective study is expected to provide a novel diagnostic method to predict DCI before aneurysmal obliteration in an acute stage of SAH.
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U2 - 10.1007/978-3-030-04615-6_24
DO - 10.1007/978-3-030-04615-6_24
M3 - Chapter
C2 - 31407078
AN - SCOPUS:85071280784
T3 - Acta Neurochirurgica, Supplementum
SP - 161
EP - 164
BT - Acta Neurochirurgica, Supplementum
PB - Springer-Verlag Wien
ER -