Role of computational fluid dynamics for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: Study protocol for a multicenter prospective study

CFD3 Study Group

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Background: Delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Recently, we reported the possibility that computational fluid dynamics (CFD) could predict DCI in terms of the cross-sectional area and flow velocity of the ipsilateral extracranial internal carotid and distal parent arteries in a single-center retrospective study. Methods: This is a multicenter, prospective, cohort study. Patients with aneurysmal SAH will undergo CFD analyses using preoperative three-dimensional computed tomography angiography, and we will investigate hemodynamic features of cerebral arteries in an acute stage of SAH. Primary outcome measures will be CFD features in patients with subsequent occurrence of DCI. Secondary outcome measures will be CFD features in patients with subsequent occurrence of cerebral vasospasm and cerebral infarction and the relationships with eventual modified Rankin scale score at 3 months. Conclusions: The present protocol for a multicenter prospective study is expected to provide a novel diagnostic method to predict DCI before aneurysmal obliteration in an acute stage of SAH.

Original languageEnglish
Title of host publicationActa Neurochirurgica, Supplementum
PublisherSpringer-Verlag Wien
Pages161-164
Number of pages4
DOIs
Publication statusPublished - 2020

Publication series

NameActa Neurochirurgica, Supplementum
Volume127
ISSN (Print)0065-1419
ISSN (Electronic)2197-8395

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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