Role of ghrelin in the regulation of vasopressin release in conscious rats

Seiji Ishizaki, Takashi Murase, Yoshihisa Sugimura, Satoshi Kakiya, Hisashi Yokoi, Kazushige Tachikawa, Hiroshi Arima, Yoshitaka Miura, Yutaka Oiso

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

GH secretagogue (GHS) is a small, synthetic compound that has the potential to stimulate GH release via its specific receptors (GHS-R). Ghrelin is a novel 28-amino acid peptide recently isolated from human and rat stomach, and it is thought to be the endogenous ligand for GHS-R. Ghrelin has a variety of physiological functions such as the stimulation of GH release or the increase of food intake by activating NPY neurons. In the present study, we investigated the effects of ghrelin on AVP release in conscious rats. Intracerebroventricular (icv) administration of ghrelin increased the plasma AVP concentration in a dose-dependent manner (1-1000 pmol/rat), and its effect was observed as late as 60 min after the administration. Icv injection of ghrelin caused no significant change in plasma osmolality, plasma volume, or arterial blood pressure. Iv administration of ghrelin (10 nmol/rat) also increased the plasma AVP concentration, which was accompanied by a significant decrease in arterial blood pressure. Pretreatment with antiserum against NPY significantly reduced the plasma AVP increase induced by icv administration of ghrelin. These results suggest that ghrelin plays a stimulatory role in AVP release, which is possibly mediated by NPY neurons.

Original languageEnglish
Pages (from-to)1589-1593
Number of pages5
JournalEndocrinology
Volume143
Issue number5
DOIs
Publication statusPublished - 01-01-2002

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Ghrelin
Vasopressins
Arterial Pressure
Neurons
Plasma Volume
Osmolar Concentration
Immune Sera
Stomach
Eating
Ligands
Amino Acids
Peptides
Injections

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Ishizaki, S., Murase, T., Sugimura, Y., Kakiya, S., Yokoi, H., Tachikawa, K., ... Oiso, Y. (2002). Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology, 143(5), 1589-1593. https://doi.org/10.1210/endo.143.5.8804
Ishizaki, Seiji ; Murase, Takashi ; Sugimura, Yoshihisa ; Kakiya, Satoshi ; Yokoi, Hisashi ; Tachikawa, Kazushige ; Arima, Hiroshi ; Miura, Yoshitaka ; Oiso, Yutaka. / Role of ghrelin in the regulation of vasopressin release in conscious rats. In: Endocrinology. 2002 ; Vol. 143, No. 5. pp. 1589-1593.
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Ishizaki, S, Murase, T, Sugimura, Y, Kakiya, S, Yokoi, H, Tachikawa, K, Arima, H, Miura, Y & Oiso, Y 2002, 'Role of ghrelin in the regulation of vasopressin release in conscious rats', Endocrinology, vol. 143, no. 5, pp. 1589-1593. https://doi.org/10.1210/endo.143.5.8804

Role of ghrelin in the regulation of vasopressin release in conscious rats. / Ishizaki, Seiji; Murase, Takashi; Sugimura, Yoshihisa; Kakiya, Satoshi; Yokoi, Hisashi; Tachikawa, Kazushige; Arima, Hiroshi; Miura, Yoshitaka; Oiso, Yutaka.

In: Endocrinology, Vol. 143, No. 5, 01.01.2002, p. 1589-1593.

Research output: Contribution to journalArticle

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Ishizaki S, Murase T, Sugimura Y, Kakiya S, Yokoi H, Tachikawa K et al. Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology. 2002 Jan 1;143(5):1589-1593. https://doi.org/10.1210/endo.143.5.8804