Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Hiromi Yamashita, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Yoshihito Nakagawa, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: There have been reports showing the protective role of inducible Heat-shock protein (HSP) 70 in gastric epithelial cells. An A to G transition at the 1267 position HSP70-2 gene has been shown to be associated with a different level of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of peptic ulcer diseases in a Japanese population. Methodology: A total of 519 subjects participated in this study. All subjects underwent upper gastroscopy. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene in all the subjects. Results: After gastroscopy, 109, 53 and 357 subjects were diagnosed as gastric ulcer, duodenal ulcer and non-ulcer subjects, respectively. Although, there were no significant differences of HSP70-2 genotype distributions among non-ulcer subjects, overall ulcer, gastric and duodenal ulcers when the subjects were divided into two groups according to age distribution, logistic regression analysis showed that the BB genotype increased the risk of duodenal ulcer in subjects 60 years and older. (Gender, status of H. pylori infection and NSAID use adjusted OR=3.12, 95%CI=1.33-7.35, p=0.009). Conclusions: It appears that polymorphism of HSP70-2 gene is not directly associated with the susceptibility to peptic ulcer diseases but BB genotype is associated with an increased risk of duodenal ulcer in older subjects in the Japanese population.

Original languageEnglish
Pages (from-to)426-429
Number of pages4
JournalHepato-gastroenterology
Volume59
Issue number114
DOIs
Publication statusPublished - 01-03-2012

Fingerprint

HSP70 Heat-Shock Proteins
Duodenal Ulcer
Peptic Ulcer
Genotype
Gastroscopy
Stomach Ulcer
Population
Genes
Pylorus
Age Distribution
Non-Steroidal Anti-Inflammatory Agents
Restriction Fragment Length Polymorphisms
Ulcer
Stomach
Logistic Models
Epithelial Cells
Regression Analysis
Messenger RNA
Infection

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, T., Arisawa, T., Shibata, T., Yamashita, H., Nakamura, M., Yoshioka, D., ... Hirata, I. (2012). Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population. Hepato-gastroenterology, 59(114), 426-429. https://doi.org/10.5754/hge09606
Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Shibata, Tomoyuki ; Yamashita, Hiromi ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Fujita, Hiroshi ; Nakagawa, Yoshihito ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Makoto ; Nakano, Hiroshi ; Hirata, Ichiro. / Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population. In: Hepato-gastroenterology. 2012 ; Vol. 59, No. 114. pp. 426-429.
@article{ac0bd2e1b33b4a3d9d543670e462e46b,
title = "Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population",
abstract = "Background/Aims: There have been reports showing the protective role of inducible Heat-shock protein (HSP) 70 in gastric epithelial cells. An A to G transition at the 1267 position HSP70-2 gene has been shown to be associated with a different level of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of peptic ulcer diseases in a Japanese population. Methodology: A total of 519 subjects participated in this study. All subjects underwent upper gastroscopy. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene in all the subjects. Results: After gastroscopy, 109, 53 and 357 subjects were diagnosed as gastric ulcer, duodenal ulcer and non-ulcer subjects, respectively. Although, there were no significant differences of HSP70-2 genotype distributions among non-ulcer subjects, overall ulcer, gastric and duodenal ulcers when the subjects were divided into two groups according to age distribution, logistic regression analysis showed that the BB genotype increased the risk of duodenal ulcer in subjects 60 years and older. (Gender, status of H. pylori infection and NSAID use adjusted OR=3.12, 95{\%}CI=1.33-7.35, p=0.009). Conclusions: It appears that polymorphism of HSP70-2 gene is not directly associated with the susceptibility to peptic ulcer diseases but BB genotype is associated with an increased risk of duodenal ulcer in older subjects in the Japanese population.",
author = "Tomomitsu Tahara and Tomiyasu Arisawa and Tomoyuki Shibata and Hiromi Yamashita and Masakatsu Nakamura and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Yoshihito Nakagawa and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Makoto Watanabe and Hiroshi Nakano and Ichiro Hirata",
year = "2012",
month = "3",
day = "1",
doi = "10.5754/hge09606",
language = "English",
volume = "59",
pages = "426--429",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "114",

}

Tahara, T, Arisawa, T, Shibata, T, Yamashita, H, Nakamura, M, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nakagawa, Y, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, M, Nakano, H & Hirata, I 2012, 'Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population', Hepato-gastroenterology, vol. 59, no. 114, pp. 426-429. https://doi.org/10.5754/hge09606

Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Yamashita, Hiromi; Nakamura, Masakatsu; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Fujita, Hiroshi; Nakagawa, Yoshihito; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Makoto; Nakano, Hiroshi; Hirata, Ichiro.

In: Hepato-gastroenterology, Vol. 59, No. 114, 01.03.2012, p. 426-429.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Shibata, Tomoyuki

AU - Yamashita, Hiromi

AU - Nakamura, Masakatsu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nakagawa, Yoshihito

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Background/Aims: There have been reports showing the protective role of inducible Heat-shock protein (HSP) 70 in gastric epithelial cells. An A to G transition at the 1267 position HSP70-2 gene has been shown to be associated with a different level of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of peptic ulcer diseases in a Japanese population. Methodology: A total of 519 subjects participated in this study. All subjects underwent upper gastroscopy. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene in all the subjects. Results: After gastroscopy, 109, 53 and 357 subjects were diagnosed as gastric ulcer, duodenal ulcer and non-ulcer subjects, respectively. Although, there were no significant differences of HSP70-2 genotype distributions among non-ulcer subjects, overall ulcer, gastric and duodenal ulcers when the subjects were divided into two groups according to age distribution, logistic regression analysis showed that the BB genotype increased the risk of duodenal ulcer in subjects 60 years and older. (Gender, status of H. pylori infection and NSAID use adjusted OR=3.12, 95%CI=1.33-7.35, p=0.009). Conclusions: It appears that polymorphism of HSP70-2 gene is not directly associated with the susceptibility to peptic ulcer diseases but BB genotype is associated with an increased risk of duodenal ulcer in older subjects in the Japanese population.

AB - Background/Aims: There have been reports showing the protective role of inducible Heat-shock protein (HSP) 70 in gastric epithelial cells. An A to G transition at the 1267 position HSP70-2 gene has been shown to be associated with a different level of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of peptic ulcer diseases in a Japanese population. Methodology: A total of 519 subjects participated in this study. All subjects underwent upper gastroscopy. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene in all the subjects. Results: After gastroscopy, 109, 53 and 357 subjects were diagnosed as gastric ulcer, duodenal ulcer and non-ulcer subjects, respectively. Although, there were no significant differences of HSP70-2 genotype distributions among non-ulcer subjects, overall ulcer, gastric and duodenal ulcers when the subjects were divided into two groups according to age distribution, logistic regression analysis showed that the BB genotype increased the risk of duodenal ulcer in subjects 60 years and older. (Gender, status of H. pylori infection and NSAID use adjusted OR=3.12, 95%CI=1.33-7.35, p=0.009). Conclusions: It appears that polymorphism of HSP70-2 gene is not directly associated with the susceptibility to peptic ulcer diseases but BB genotype is associated with an increased risk of duodenal ulcer in older subjects in the Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=84860577473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860577473&partnerID=8YFLogxK

U2 - 10.5754/hge09606

DO - 10.5754/hge09606

M3 - Article

C2 - 22353510

AN - SCOPUS:84860577473

VL - 59

SP - 426

EP - 429

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 114

ER -

Tahara T, Arisawa T, Shibata T, Yamashita H, Nakamura M, Yoshioka D et al. Role of Heat-Shock Protein (HSP) 70-2 genotype in peptic ulcer in Japanese population. Hepato-gastroenterology. 2012 Mar 1;59(114):426-429. https://doi.org/10.5754/hge09606