Role of matrix metalloproteinases in the pathogenesis of childhood gastroenteritis

Yoshiki Kawamura, Kensei Gotoh, Nao Takeuchi, Hiroki Miura, Naoko Nishimura, Takao Ozaki, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the pathogenesis of gastrointestinal diseases, such as rotavirus gastroenteritis (GE). Kinetics of these biomarkers were examined in paired serum samples collected from bacterial enteritis patients with Campylobacter (n=2) and Salmonella (n=4) and viral GE patients with rotavirus (n=27), norovirus (n=25), and adenovirus (n=11). At the time of hospital admission, all viral GE patients demonstrated increased MMP-9 and decreased MMP-2 and TIMP-2 serum levels. In contrast to viral GE patients, serum MMP-9 levels were not elevated at the time of hospital admission but elevated at the time of discharge; serum MMP-2 and TIMP-2 levels were decreased both at the time of admission and discharge in bacterial enteritis patients. Interestingly, the kinetics of serum MMP-2, MMP-9, and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients. Thus, the involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the etiological agent. Further studies are required to verify whether the extent of the bacterial enteritis or age of the patients influences these serum biomarkers.

Original languageEnglish
Pages (from-to)1341-1346
Number of pages6
JournalJournal of Medical Virology
Volume88
Issue number8
DOIs
Publication statusPublished - 01-08-2016

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Gastroenteritis
Matrix Metalloproteinases
Matrix Metalloproteinase Inhibitors
Enteritis
Tissue Inhibitor of Metalloproteinase-2
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Serum
Tissue Inhibitor of Metalloproteinases
Rotavirus
Biomarkers
Norovirus
Campylobacter
Gastrointestinal Diseases
Adenoviridae
Salmonella

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Kawamura, Yoshiki ; Gotoh, Kensei ; Takeuchi, Nao ; Miura, Hiroki ; Nishimura, Naoko ; Ozaki, Takao ; Yoshikawa, Tetsushi. / Role of matrix metalloproteinases in the pathogenesis of childhood gastroenteritis. In: Journal of Medical Virology. 2016 ; Vol. 88, No. 8. pp. 1341-1346.
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Role of matrix metalloproteinases in the pathogenesis of childhood gastroenteritis. / Kawamura, Yoshiki; Gotoh, Kensei; Takeuchi, Nao; Miura, Hiroki; Nishimura, Naoko; Ozaki, Takao; Yoshikawa, Tetsushi.

In: Journal of Medical Virology, Vol. 88, No. 8, 01.08.2016, p. 1341-1346.

Research output: Contribution to journalArticle

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