Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis—A Review

Eun Joo Shin, Hai Quyen Tran, Phuong Tram Nguyen, Ji Hoon Jeong, Seung Yeol Nah, Choon Gon Jang, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles with dynamic nature. Evidence indicated that exposure to MA can disturb mitochondrial energetic metabolism by inhibiting the Krebs cycle and electron transport chain. Alterations in mitochondrial dynamic processes, including mitochondrial biogenesis, mitophagy, and fusion/fission, have recently been shown to contribute to dopaminergic toxicity induced by MA. Furthermore, it was demonstrated that MA-induced mitochondrial impairment enhances susceptibility to oxidative stress, pro-apoptosis, and neuroinflammation in a positive feedback loop. Protein kinase Cδ has emerged as a potential mediator between mitochondrial impairment and oxidative stress, pro-apoptosis, or neuroinflammation in MA neurotoxicity. Understanding the role and underlying mechanism of mitochondrial impairment could provide a molecular target to prevent or alleviate dopaminergic toxicity induced by MA.

Original languageEnglish
Pages (from-to)57-69
Number of pages13
JournalNeurochemical Research
Volume43
Issue number1
DOIs
Publication statusPublished - 01-01-2018

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Mitochondria
Oxidative stress
Methamphetamine
Oxidative Stress
Toxicity
Mitochondrial Dynamics
Mitochondrial Degradation
Apoptosis
Citric Acid Cycle
Organelle Biogenesis
Amphetamine
Electron Transport
Metabolism
Organelles
Protein Kinase C
Fusion reactions
Feedback

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Shin, Eun Joo ; Tran, Hai Quyen ; Nguyen, Phuong Tram ; Jeong, Ji Hoon ; Nah, Seung Yeol ; Jang, Choon Gon ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity : Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis—A Review. In: Neurochemical Research. 2018 ; Vol. 43, No. 1. pp. 57-69.
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Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity : Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis—A Review. / Shin, Eun Joo; Tran, Hai Quyen; Nguyen, Phuong Tram; Jeong, Ji Hoon; Nah, Seung Yeol; Jang, Choon Gon; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Neurochemical Research, Vol. 43, No. 1, 01.01.2018, p. 57-69.

Research output: Contribution to journalArticle

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