Role of nitric oxide in the effect of aging on spatial memory in rats

Yukihiro Noda, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Since there is evidence that nitric oxide (NO) plays an important role as a diffusible messenger in learning and memory, we examined the role played by NO in the effect of aging on spatial memory in rats. The performance of aged rats (30 months old) in a radial-arm maze task was significantly impaired compared to that of adult rats (3 months old). The number of neurons containing NADPH-diaphorase (NADPH-d) reactivity in the cerebral cortex and striatum of aged rats was significantly less than that in the adult rats. The daily administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 10-60 mg/kg, i.p.) resulted in a dose-dependent impairment of acquisition in the radial-arm maze task, while it failed to affect previously acquired performance, i.e., retention, in the adult rats. The content of 5-hydroxyindoleacetic acid in the hippocampus and of 3,4-dihydroxyphenylacetic acid in the striatum was significantly decreased and increased, respectively, in the L-NAME (60 mg/kg/day)-treated adult rats compared with that in controls. These findings demonstrate that NO production in the brain may be decreased in aged rats, suggesting that this alteration may be involved in memory processes, especially in the acquisition, but not in the retention, of spatial learning in rats, and further, that endogenous NO may be involved in the regulation of dopaminc and 5-hydroxytryptamine metabolism.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalBehavioural Brain Research
Volume83
Issue number1-2
DOIs
Publication statusPublished - 01-01-1997
Externally publishedYes

Fingerprint

Nitric Oxide
NG-Nitroarginine Methyl Ester
Spatial Memory
NADPH Dehydrogenase
3,4-Dihydroxyphenylacetic Acid
Hydroxyindoleacetic Acid
Cerebral Cortex
Hippocampus
Serotonin
Learning
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Noda, Yukihiro ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Role of nitric oxide in the effect of aging on spatial memory in rats. In: Behavioural Brain Research. 1997 ; Vol. 83, No. 1-2. pp. 153-158.
@article{f735edf73dd54869ae19b7fb46323148,
title = "Role of nitric oxide in the effect of aging on spatial memory in rats",
abstract = "Since there is evidence that nitric oxide (NO) plays an important role as a diffusible messenger in learning and memory, we examined the role played by NO in the effect of aging on spatial memory in rats. The performance of aged rats (30 months old) in a radial-arm maze task was significantly impaired compared to that of adult rats (3 months old). The number of neurons containing NADPH-diaphorase (NADPH-d) reactivity in the cerebral cortex and striatum of aged rats was significantly less than that in the adult rats. The daily administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 10-60 mg/kg, i.p.) resulted in a dose-dependent impairment of acquisition in the radial-arm maze task, while it failed to affect previously acquired performance, i.e., retention, in the adult rats. The content of 5-hydroxyindoleacetic acid in the hippocampus and of 3,4-dihydroxyphenylacetic acid in the striatum was significantly decreased and increased, respectively, in the L-NAME (60 mg/kg/day)-treated adult rats compared with that in controls. These findings demonstrate that NO production in the brain may be decreased in aged rats, suggesting that this alteration may be involved in memory processes, especially in the acquisition, but not in the retention, of spatial learning in rats, and further, that endogenous NO may be involved in the regulation of dopaminc and 5-hydroxytryptamine metabolism.",
author = "Yukihiro Noda and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "1997",
month = "1",
day = "1",
doi = "10.1016/S0166-4328(97)86060-3",
language = "English",
volume = "83",
pages = "153--158",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1-2",

}

Role of nitric oxide in the effect of aging on spatial memory in rats. / Noda, Yukihiro; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 83, No. 1-2, 01.01.1997, p. 153-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of nitric oxide in the effect of aging on spatial memory in rats

AU - Noda, Yukihiro

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Since there is evidence that nitric oxide (NO) plays an important role as a diffusible messenger in learning and memory, we examined the role played by NO in the effect of aging on spatial memory in rats. The performance of aged rats (30 months old) in a radial-arm maze task was significantly impaired compared to that of adult rats (3 months old). The number of neurons containing NADPH-diaphorase (NADPH-d) reactivity in the cerebral cortex and striatum of aged rats was significantly less than that in the adult rats. The daily administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 10-60 mg/kg, i.p.) resulted in a dose-dependent impairment of acquisition in the radial-arm maze task, while it failed to affect previously acquired performance, i.e., retention, in the adult rats. The content of 5-hydroxyindoleacetic acid in the hippocampus and of 3,4-dihydroxyphenylacetic acid in the striatum was significantly decreased and increased, respectively, in the L-NAME (60 mg/kg/day)-treated adult rats compared with that in controls. These findings demonstrate that NO production in the brain may be decreased in aged rats, suggesting that this alteration may be involved in memory processes, especially in the acquisition, but not in the retention, of spatial learning in rats, and further, that endogenous NO may be involved in the regulation of dopaminc and 5-hydroxytryptamine metabolism.

AB - Since there is evidence that nitric oxide (NO) plays an important role as a diffusible messenger in learning and memory, we examined the role played by NO in the effect of aging on spatial memory in rats. The performance of aged rats (30 months old) in a radial-arm maze task was significantly impaired compared to that of adult rats (3 months old). The number of neurons containing NADPH-diaphorase (NADPH-d) reactivity in the cerebral cortex and striatum of aged rats was significantly less than that in the adult rats. The daily administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 10-60 mg/kg, i.p.) resulted in a dose-dependent impairment of acquisition in the radial-arm maze task, while it failed to affect previously acquired performance, i.e., retention, in the adult rats. The content of 5-hydroxyindoleacetic acid in the hippocampus and of 3,4-dihydroxyphenylacetic acid in the striatum was significantly decreased and increased, respectively, in the L-NAME (60 mg/kg/day)-treated adult rats compared with that in controls. These findings demonstrate that NO production in the brain may be decreased in aged rats, suggesting that this alteration may be involved in memory processes, especially in the acquisition, but not in the retention, of spatial learning in rats, and further, that endogenous NO may be involved in the regulation of dopaminc and 5-hydroxytryptamine metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0031080881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031080881&partnerID=8YFLogxK

U2 - 10.1016/S0166-4328(97)86060-3

DO - 10.1016/S0166-4328(97)86060-3

M3 - Article

C2 - 9062675

AN - SCOPUS:0031080881

VL - 83

SP - 153

EP - 158

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1-2

ER -