Role of nociceptin systems in learning and memory

Yukihiro Noda, Takayoshi Mamiya, Toshiya Manabe, Miyuki Nishi, Hiroshi Takeshima, Toshitaka Nabeshima

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1063-1069
Number of pages7
JournalPeptides
Volume21
Issue number7
DOIs
Publication statusPublished - 01-07-2000
Externally publishedYes

Fingerprint

Learning
Data storage equipment
Hippocampal CA1 Region
Aptitude
Water
Long-Term Potentiation
Knockout Mice
nociceptin
naloxone benzoylhydrazone
nociceptin receptor

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Noda, Y., Mamiya, T., Manabe, T., Nishi, M., Takeshima, H., & Nabeshima, T. (2000). Role of nociceptin systems in learning and memory. Peptides, 21(7), 1063-1069. https://doi.org/10.1016/S0196-9781(00)00244-8
Noda, Yukihiro ; Mamiya, Takayoshi ; Manabe, Toshiya ; Nishi, Miyuki ; Takeshima, Hiroshi ; Nabeshima, Toshitaka. / Role of nociceptin systems in learning and memory. In: Peptides. 2000 ; Vol. 21, No. 7. pp. 1063-1069.
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Noda, Y, Mamiya, T, Manabe, T, Nishi, M, Takeshima, H & Nabeshima, T 2000, 'Role of nociceptin systems in learning and memory', Peptides, vol. 21, no. 7, pp. 1063-1069. https://doi.org/10.1016/S0196-9781(00)00244-8

Role of nociceptin systems in learning and memory. / Noda, Yukihiro; Mamiya, Takayoshi; Manabe, Toshiya; Nishi, Miyuki; Takeshima, Hiroshi; Nabeshima, Toshitaka.

In: Peptides, Vol. 21, No. 7, 01.07.2000, p. 1063-1069.

Research output: Contribution to journalReview article

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T1 - Role of nociceptin systems in learning and memory

AU - Noda, Yukihiro

AU - Mamiya, Takayoshi

AU - Manabe, Toshiya

AU - Nishi, Miyuki

AU - Takeshima, Hiroshi

AU - Nabeshima, Toshitaka

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AB - This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. Copyright (C) 2000 Elsevier Science Inc.

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Noda Y, Mamiya T, Manabe T, Nishi M, Takeshima H, Nabeshima T. Role of nociceptin systems in learning and memory. Peptides. 2000 Jul 1;21(7):1063-1069. https://doi.org/10.1016/S0196-9781(00)00244-8