Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

Shingo Kato, Yoshikazu Tsuzuki, Ryota Hokari, Yoshikiyo Okada, Junichi Miyazaki, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Hidekazu Suzuki, Toshitaka Nabeshima, Soichiro Miura

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23 Citations (Scopus)

Abstract

Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalJournal of Neuroimmunology
Volume161
Issue number1-2
DOIs
Publication statusPublished - 04-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Kato, S., Tsuzuki, Y., Hokari, R., Okada, Y., Miyazaki, J., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S., Itoh, K., Suzuki, H., Nabeshima, T., & Miura, S. (2005). Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. Journal of Neuroimmunology, 161(1-2), 21-28. https://doi.org/10.1016/j.jneuroim.2004.12.006