TY - JOUR
T1 - Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis
AU - Kato, Shingo
AU - Tsuzuki, Yoshikazu
AU - Hokari, Ryota
AU - Okada, Yoshikiyo
AU - Miyazaki, Junichi
AU - Matsuzaki, Koji
AU - Iwai, Atsuhiro
AU - Kawaguchi, Atsushi
AU - Nagao, Shigeaki
AU - Itoh, Kazuro
AU - Suzuki, Hidekazu
AU - Nabeshima, Toshitaka
AU - Miura, Soichiro
PY - 2005/4
Y1 - 2005/4
N2 - Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
AB - Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
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U2 - 10.1016/j.jneuroim.2004.12.006
DO - 10.1016/j.jneuroim.2004.12.006
M3 - Article
C2 - 15748940
AN - SCOPUS:20044374866
VL - 161
SP - 21
EP - 28
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -