Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

Shingo Kato; Yoshikazu Tsuzuki; Ryota Hokari; Yoshikiyo Okada; Junichi Miyazaki; Koji Matsuzaki; Atsuhiro Iwai; Atsushi Kawaguchi; Shigeaki Nagao; Kazuro Itoh; Hidekazu Suzuki; Toshitaka Nabeshima; Soichiro Miura

doi:10.1016/j.jneuroim.2004.12.006

Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

Shingo Kato
, Yoshikazu Tsuzuki
, Ryota Hokari
, Yoshikiyo Okada
, Junichi Miyazaki
, Koji Matsuzaki
, Atsuhiro Iwai
, Atsushi Kawaguchi
, Shigeaki Nagao
, Kazuro Itoh
, Hidekazu Suzuki
, Toshitaka Nabeshima
, Soichiro Miura

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	161
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.12.006
Publication status	Published - 04-2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2004.12.006

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@article{c0623d04bf044e5fb79135bc70c2211a,

title = "Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis",

abstract = "Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.",

author = "Shingo Kato and Yoshikazu Tsuzuki and Ryota Hokari and Yoshikiyo Okada and Junichi Miyazaki and Koji Matsuzaki and Atsuhiro Iwai and Atsushi Kawaguchi and Shigeaki Nagao and Kazuro Itoh and Hidekazu Suzuki and Toshitaka Nabeshima and Soichiro Miura",

note = "Funding Information: This study was supported in part by grants from National Defense Medical College and Keio University School of Medicine. This study was also supported by grants from the Smoking Research Foundation and the Food Science Institute Foundation.",

year = "2005",

month = apr,

doi = "10.1016/j.jneuroim.2004.12.006",

language = "English",

volume = "161",

pages = "21--28",

journal = "Journal of Neuroimmunology",

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T1 - Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

AU - Kato, Shingo

AU - Tsuzuki, Yoshikazu

AU - Hokari, Ryota

AU - Okada, Yoshikiyo

AU - Miyazaki, Junichi

AU - Matsuzaki, Koji

AU - Iwai, Atsuhiro

AU - Kawaguchi, Atsushi

AU - Nagao, Shigeaki

AU - Itoh, Kazuro

AU - Suzuki, Hidekazu

AU - Nabeshima, Toshitaka

AU - Miura, Soichiro

N1 - Funding Information: This study was supported in part by grants from National Defense Medical College and Keio University School of Medicine. This study was also supported by grants from the Smoking Research Foundation and the Food Science Institute Foundation.

PY - 2005/4

Y1 - 2005/4

N2 - Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.

AB - Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.

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M3 - Article

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AN - SCOPUS:20044374866

SN - 0165-5728

VL - 161

SP - 21

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

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All Science Journal Classification (ASJC) codes

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